Aminothiol-conjugates, compositions, and methods of use thereof

A method of treating a neoplastic condition in a subject in need thereof, said method comprising:

• administering to said subject a combination therapy comprising:
• (i) an aminothiol-conjugate of Formula (I):
• wherein
• is optional and, if present, is an atom, a molecule, or a macromolecule;
• is a linker group, wherein the linker group is a polymer, a section of a polymer, an arm of a polymer, an arm of a copolymer, or a branch of a dendrimer;
• wherein each
• can be the same or different;
• R1, R2, and R3 are independently selected from hydrogen and C1-6 alkyl;
• m is 1 to 100,000;
• n is 1 to 10;
• and
• p is independently 0 to 2,500,
• or a pharmaceutically acceptable salt, hydrate, polymorph, or solvate thereof, and
• (ii) an anti-neoplastic drug, wherein the combination therapy is administered in an amount effective to treat the neoplastic condition in the subject.

A combination therapeutic comprising:

• (i) an aminothiol-conjugate of Formula (I):
• wherein
• is optional and, if present, is an atom, a molecule, or a macromolecule;
• is a linker group, wherein the linker group is a polymer, a section of a polymer, an arm of a polymer, an arm of a copolymer, or a branch of a dendrimer;
• wherein each
• can be the same or different;
• R1, R2, and R3 are independently selected from hydrogen and C1-6 alkyl;
• m is 1 to 100,000;
• n is 1 to 10;
• and
• p is independently 0 to 2,500,
• or a pharmaceutically acceptable salt, hydrate, polymorph, or solvate thereof, and
• (ii) an anti-neoplastic drug.

A method of treating a subject in need of antimicrobial treatment, said method comprising:

• administering to said subject a combination therapy comprising:
• (i) an aminothiol-conjugate of Formula (I):
• wherein
• is optional and, if present, is an atom, a molecule, or a macromolecule;
• is a linker group, wherein the linker group is a polymer, a section of a polymer, an arm of a polymer, an arm of a copolymer, or a branch of a dendrimer;
• wherein each
• can be the same or different;
• R1, R2, and R3 are independently selected from hydrogen and C1-6 alkyl;
• m is 1 to 100,000;
• n is 1 to 10;
• and
• p is independently 0 to 2,500,
• or a pharmaceutically acceptable salt, hydrate, polymorph, or solvate thereof, and (ii) an antimicrobial drug, wherein the combination therapy is administered in an amount effective to treat a microbial condition in the subject.

A combination therapeutic comprising:

• (i) an aminothiol-conjugate of Formula (I):
• wherein
• is optional and, if present, is an atom, a molecule, or a macromolecule;
• is a linker group, where the linker group is a polymer, a section of a polymer, an arm of a polymer, an arm of a copolymer, or a branch of a dendrimer;
• wherein each
• can be the same or different;
• R1, R2, and R3 are independently selected from hydrogen and C1-6 alkyl;
• m is 1 to 100,000;
• n is 1 to 10;
• and
• p is independently 0 to 2,500,
• or a pharmaceutically acceptable salt, hydrate, polymorph, or solvate thereof, and
• (ii) an antimicrobial drug.