Ventricular Arrhythmias and Related Methods
AssigneeUniversity of Massachusetts
InventorJohn Kevin Donahue
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Abstract
In some aspects, the disclosure relates methods for treating ventricular tachycardia in a subject. In some embodiments, methods of the disclosure comprise measuring action potential durations and/or expression levels of KCNE3 and/or KCNE4 in a subject. In some aspects, the disclosure relates to methods and compositions for reducing or inhibiting the activity of KCNE3 and/or KCNE4, for example, in subjects having ventricular tachycardia.
Claims17
A method for treating a subject having a cardiac ventricular tachycardia (VT) circuit, the method comprising administering a composition to a subject, wherein the composition inhibits expression of KCNE3, inhibits expression of KCNE4, decreases KCNE3 activity, decreases KCNE4 activity, or a combination thereof.
Dependencies are inferred from the claim text.