Graftable biocidal linkers and polymers and uses thereof
AssigneeDebogy Molecular, Inc.
InventorOthman BOULOUSSA
Life of this patent
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Abstract
Ready-to-graft compositions comprising polymers and Surrounding Tissue compounds and at least one grafting enhancer and/or grafting adjuvant, surfaces grafted to same, and methods of making and using the same for controlling the growth of at least one bacteria, fungi, protozoa, or virus are disclosed.
Claims74
A composition comprising a polymer comprising at least one moiety of formula (XVIIa) and at least one grafting enhancer and/or grafting adjuvant, optionally a cross-linking reagent:
- wherein in formula (XVIIa):
- G is a single bond or a linking group;
- each R3 is independently optionally substituted alkoxy;
- R4 is independently optionally substituted alkyl;
- v is an integer from 3 to 10;
- and
- w is an integer from 3 to 10.
A composition comprising a polymer comprising at least one moiety of formula (XXI) and at least one grafting enhancer and/or grafting adjuvant, optionally a cross-linking reagent:
- wherein in formula (XXI):
- each R3 is independently optionally substituted alkoxy;
- v is an integer from 3 to 10;
- and
- w is an integer from 3 to 10.
The composition of claim 12 or 13, wherein the polymer comprises at least one moiety of formula (XXIb):
A composition comprising a polymer comprising at least one moiety of formula (II) and at least one grafting enhancer and/or grafting adjuvant, optionally a cross-linking reagent:
A composition comprising a polymer comprising at least one moiety of formula (V) and at least one grafting enhancer and/or grafting adjuvant, optionally a cross-linking reagent:
- wherein in formula (V):
- each R2 is independently optionally substituted alkyl.
A composition comprising a polyethylenimine (PEI) polymer comprising at least one moiety of formula (IXa), formula (IXb), or formula (IXh) and at least one grafting enhancer and/or grafting adjuvant, optionally a cross-linking reagent:
- wherein in formula (IXa), formula (IXb), and formula (IXh):
- each R2 is independently optionally substituted alkyl.
A composition comprising a polyethylenimine (PEI) polymer comprising at least one moiety of formula (IXf), or any substructure thereof, and at least one grafting enhancer and/or grafting adjuvant, optionally a cross-linking reagent:
- wherein in formula (IXf):
- each R5 is independently C10 alkyl or
- with the proviso that at least one R5 is a moiety of formula (Ia):
A composition comprising a polyethylenimine (PEI) polymer comprising at least one moiety of formula (IXg), or any substructure thereof, and at least one grafting enhancer and/or grafting adjuvant, optionally a cross-linking reagent thereof:
- wherein in formula (IXg):
- each R5 is independently C6 alkyl or
- with the proviso that at least one R5 is a moiety of formula (Ia):
A composition comprising a polyethylenimine (PEI) polymer comprising at least one moiety of formula (XIa), and at least one grafting enhancer and/or grafting adjuvant, optionally a cross-linking reagent:
- wherein in formula (XIa):
- each R3 is independently optionally substituted alkoxy, optionally methoxy;
- and
- v is an integer from 3 to 10.
A composition comprising a polyethylenimine (PEI) polymer comprising at least one moiety of formula (XIb), or any substructure thereof, and at least one grafting enhancer and/or grafting adjuvant, optionally a cross-linking reagent:
- wherein in formula (XIb):
- each R4 is independently optionally substituted alkyl;
- and
- each R5 is independently optionally substituted alkyl or a moiety of formula (XIa):
- each R3 is independently optionally substituted alkoxy;
- and
- v is an integer from 3 to 10,
- with the proviso that at least one R5 is a moiety of formula (XIa):
A composition comprising polyethylenimine (PEI) polymer comprising at least one moiety of formula (XIc), or any substructure thereof, and at least one grafting enhancer and/or grafting adjuvant, optionally a cross-linking reagent:
- wherein in formula (XIc):
- each R5 is independently C6 alkyl or
- each R3 is independently optionally substituted alkoxy;
- and
- v is an integer from 3 to 10,
- with the proviso that at least one R5 is
A method of preparing a conjugated biomolecule, the method comprising grafting a catechol moiety of formula (Ib) on to a surface, and reacting the compound of formula (Ib′) with a biomolecule of formula (XLb):
- wherein in formula (Ib′):
- X comprises a reactive group and/or a leaving group;
- wherein in formula (XLb):
- Z′ comprises a reactive group and/or a leaving group;
- and
- B is a biomolecule.
A solution comprising an alcohol and a polyethylenimine (PEI) polymer comprising at least one moiety of formula (XIa), and at least one grafting enhancer and/or grafting adjuvant, optionally a cross-linking reagent:
- wherein in formula (XIa):
- each R3 is independently optionally substituted alkoxy, optionally methoxy;
- and
- v is an integer from 3 to 10;
- wherein the solution comprises at least one moiety of formula (XIa) in an amount of about 70% to about 80%, optionally about 75% by weight, based on the weight of the solution, and the at least one grafting enhancer and/or grafting adjuvant, optionally a cross-linking reagent, in an amount of about 20% to about 30% (v/v), optionally about 25% (v/v), of the solution.
Dependencies are inferred from the claim text.