Pre-targeting
OwnerSophie Poty, Jean-Pierre Pouget +5inventors
InventorsSophie Poty, Jean-Pierre Pouget, Tony Lahoutte, Matthias Bruno Lieven D'Huyvetter, Yana Dekempeneer, Francis Santens, Laurent Navarro
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Abstract
The present invention relates to the field of VHHs that may be used in pre-targeting combinations comprising the VHH and a labelled compound. Depending on the application, the labelled compound may comprise a radionuclide. The pre-targeting combinations are preferably for use in the treatment and/or diagnosis of a cancer.
Claims27
A method of treating a patient in need thereof, said method comprising:
- administration of a heavy chain variable domain derived from a heavy chain antibody (VHH), or a fragment thereof, said VHH or said fragment comprising a click group, wherein said click group has not underwent a click reaction upon administration of said VHH or said fragment thereof to said patient.
A heavy chain variable domain derived from a heavy chain antibody (VHH), or a fragment thereof, comprising a click group, wherein said VHH, or said fragment thereof, is able to specifically bind an antigen with a dissociation constant (koff) equal to or smaller than 10−2 s−1.
Dependencies are inferred from the claim text.