US 2025/0122188 A1Published application

Modulators of the integrated stress pathway

AssigneesCalico Life Sciences LLC, AbbVie Inc.

InventorsCarmela Sidrauski, Marina Pliushchev, Jennifer M. Frost, Lawrence A. Black, Xiangdong Xu, Ramzi Farah Sweis, Lei Shi, Qingwei Zhang, Yunsong Tong, Charles W. Hutchins, SeungWon Chung, Michael J. Dart

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Abstract

Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Claims4

Dependent claims

-62. (canceled)

Dependencies are inferred from the claim text.

Facts

Application: 18/648,195Filed 26 Apr 2024
Priority: 5 May 2016
Published: 17 Apr 2025
Term ends: Not estimatedThe source records don’t support an estimate.

Classification28 codes

C07D 471/04
In which the condensed system contains two hetero rings: ortho-condensed systems
A61P 25/28
Drugs for disorders of the nervous system: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents,…
C07C 235/22
Having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides:…
C07C 311/13
Of an unsaturated carbon skeleton containing rings: the carbon skeleton containing six-membered aromatic rings

Family

Application62/332,278Us provisional application · filed 5 May 2016
Application16/098,675Continuation · filed 2 Nov 2018
Application17/103,003Continuation · filed 24 Nov 2020
Application18/648,195Continuation
US 2019/0144440 A1Published application
US 2022/0363678 A1Published application
US 2025/0122188 A1This patent

From the US filing history. Foreign family members aren’t listed.

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