Composition and method for diagnostic imaging
AssigneeSuntec Medical, Inc.
InventorsYuan-Chung Tsai, Chun-Ting Cheng, Pauline Ying Lau
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Abstract
The present invention provides compositions and methods for diagnostic imaging. The composition comprises micelles having an outer shell comprising one or more polymer-flavonoid conjugates, optionally an inner shell comprising one or more flavonoid oligomer, and a diagnostic imaging agent encapsulated within the shells. The present invention also provides methods for performing diagnostic imaging using the compositions.
Claims20
A diagnostic imaging composition comprising micelles having an outer shell comprising one or more polymer-flavonoid conjugates, optionally an inner shell comprising one or more flavonoid oligomer, and a diagnostic imaging agent encapsulated within the shells;
- wherein the polymer is a hydrophilic polymer having a molecular weight of 1,000 to 100,000 daltons, and is selected from the group consisting of:
- poly(ethylene glycol) (PEG), hyaluronic acid, dextran, polyethylenimine, poloxamers, povidone, D-alpha-tocopheryl, and polyethylene glycol succinate;
- the flavonoid is EGCG, EC, EGC, or ECG, as shown in the structures below:
- the flavonoid oligomer comprises 2-20 flavonoids of EGCG, EC, EGC, or ECG;
- and
- the diagnostic imaging agent is a computed tomography (CT) imaging agent, a magnetic resonance imaging (MRI) imaging agent, a positron emission tomography (PET) agent, a single-photon emission computed tomography (SPECT) agent, an ultrasound agent, and a photoacoustic (PA) imaging agent.
Dependencies are inferred from the claim text.