mRNA VACCINES AGAINST TICK SALIVARY PROTEINS, AND METHODS OF USING SAME
AssigneesThe Trustees of the University of Pennsylvania, Yale University
InventorsDrew Weissman, Erol Fikrig, Sukanya Narasimhan
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Abstract
Provided are nucleoside-modified mRNA molecules encoding tick salivary antigens, and LNP vaccines comprising the mRNA molecules and methods of use thereof to treat or prevent diseases or disorders associated with a tick-borne pathogen including Lyme disease.
Claims29
A composition for inducing an immune response against at least one tick salivary antigen in a subject, the composition comprising at least one nucleoside-modified RNA molecule encoding at least one tick salivary antigen.
The composition of claim 12, wherein the at least one nucleoside-modified RNA is encapsulated within the LNP.
A method of inducing an immune response against one or more tick salivary antigen in a subject comprising administering to the subject an effective amount of a composition comprising at least one nucleoside-modified RNA molecule encoding at least one tick salivary antigen.
Dependencies are inferred from the claim text.