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US 2025/0101471 A1Published application
Microbial Production Of Fatty Diols
AssigneeGenomatica, Inc.
InventorsAndreas W. SCHIRMER, Noah HELMAN, Haibo WANG, Zhihao HU, Vikranth ARLAGADDA, Alma Itzel RAMOS-SOLIS, Elizabeth J. CLARKE
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Abstract
The disclosure relates to fatty diols and recombinant microorganisms for producing them. More particularly, the disclosure relates to recombinant microorganisms engineered to produce fatty diols via fermentation. Further encompassed is a process that uses the microorganisms to produce fatty diols from a simple carbon source.
Claims21
A recombinant microorganism for producing a 1,3 fatty diol when grown in a fermentation broth with a simple carbon source, wherein the recombinant microorganism is engineered to express:
- (a) a nucleic acid sequence encoding a polypeptide comprising thioesterase activity that can convert a 3′-hydroxy acyl-ACP to a 3′-hydroxy fatty acid;
- and
- (b) a nucleic acid sequence encoding a polypeptide comprising carboxylic acid reductase activity that can convert a 3′-hydroxy fatty acid to a 3′-hydroxy fatty aldehyde.
-27. (canceled)
Dependencies are inferred from the claim text.