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US 2025/0101381 A1Published application
Cells with increased immuno-regulatory properties and methods for their use and manufacture
AssigneeChildren's Medical Center Corporation
InventorPaolo Fiorina
Life of this patent
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Abstract
The present invention is directed to compositions and methods to increase the expression of PD-L1 and/or IDO-1 in a population of cells, the modulated cells expressing increased PD-L1 and/or IDO-1, and methods related to the immunosuppressive effects obtained by cells expressing increased PD-L1 and/or IDO-1.
Claims3
A population of modified hematopoietic stem cells (HSCs), wherein the HSCs have been modified to comprise an exogenous copy of a polynucleotide encoding PD-L1.
Dependencies are inferred from the claim text.