Respiratory syncytial virus vaccine
AssigneeModernaTX, Inc.
InventorsGiuseppe Ciaramella, Kapil Bahl, Amy Espeseth, Dai Wang, Andrew J. Bett
Life of this patent
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Abstract
The disclosure relates to respiratory syncytial vims (RSV) ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.
Claims13
1-109. (canceled)
A vaccine comprising a messenger ribonucleic acid (mRNA) formulated in a lipid nanoparticle, wherein the mRNA comprises an open reading frame (ORF) comprising nucleosides consisting of N1-methyl-pseudouridine, adenosine, guanosine, and cytidine,
- wherein the ORF encodes a respiratory syncytial virus (RSV) fusion (F) glycoprotein comprising S155C, S290C, S190F, and V207L amino acid substitutions;
- and
- wherein the lipid nanoparticle comprises a compound of Formula (I):
- wherein:
- R1 is selected from the group consisting of C5-30 alkyl, C5-20 alkenyl, and —R″M′R′;
- R2 and R3 are independently selected from the group consisting of C1-14 alkyl and C2-14 alkenyl;
- R4 is —(CH2)nQ, wherein Q is —OR, wherein n is selected from 1, 2, 3, 4, and 5;
- each R8 is H;
- each R6 is H;
- M and M′ are independently selected from —C(O)O— and —OC(O)—;
- R7 is H;
- R is H;
- R′ is selected from the group consisting of C1-18 alkyl and C2-18 alkenyl;
- R″ is selected from the group consisting of C3-14 alkyl and C3-14 alkenyl;
- and
- m is selected from 5, 6, 7, 8, 9, 10, 11, 12, and 13.
A vaccine comprising a messenger ribonucleic acid (mRNA) formulated in a lipid nanoparticle, wherein the mRNA comprises an open reading frame (ORF) comprising nucleosides consisting of N1-methyl-pseudouridine, adenosine, guanosine, and cytidine, wherein the ORF encodes an immunogenic fragment of a respiratory syncytial virus (RSV) fusion (F) glycoprotein,
- wherein the immunogenic fragment of the RSV F glycoprotein comprises S155C, S290C, S190F, and V207L amino acid substitutions;
- and
- wherein the lipid nanoparticle comprises a compound of Formula (I):
- wherein:
- R1 is selected from the group consisting of C5-30 alkyl, C5-20 alkenyl, and —R″M′R′;
- R2 and R3 are independently selected from the group consisting of C1-14 alkyl and C2-14 alkenyl;
- R4 is —(CH2)nQ, wherein Q is —OR, wherein n is selected from 1, 2, 3, 4, and 5;
- each R5 is H;
- each R6 is H;
- M and M′ are independently selected from —C(O)O— and —OC(O)—;
- R7 is H;
- R is H;
- R′ is selected from the group consisting of C1-18 alkyl and C2-18 alkenyl;
- R″ is selected from the group consisting of C3-14 alkyl and C3-14 alkenyl;
- and
- m is selected from 5, 6, 7, 8, 9, 10, 11, 12, and 13.
Dependencies are inferred from the claim text.