Method for obtaining antibody sequence

An electronic device, comprising:

• at least one processor;
• and
• a memory communicatively connected to the at least one processor;
• wherein the memory stores instructions executable by the at least one processor to perform a method for obtaining an antibody sequence, comprising:
• performing Multiple Sequence Alignment (MSA) on an antigen sequence and an initial antibody sequence respectively to obtain an antigen MSA sequence and an antibody MSA sequence;
• concatenating the antigen MSA sequence and the antibody MSA sequence, and obtaining first features of amino acids at different sequence positions in a concatenated sequence according to respective attribute features of the amino acids in the concatenated sequence, the antigen MSA sequence and the antibody MSA sequence;
• constructing a graph according to connectivity relationships among amino acids in a reference antigen-antibody complex, and obtaining second features of the amino acids at different 3D coordinates in the reference antigen-antibody complex according to respective attribute features of the amino acids in the graph;
• fusing the first features of amino acids at different sequence positions with the second features of amino acids at 3D coordinates corresponding to the different sequence positions, and obtaining probability information of each of the amino acids at different positions in the antibody sequence according to fused features;
• and
• obtaining a target antibody sequence according to the amino acids and their probability information at different positions in the antibody sequence.

A non-transitory computer-readable storage medium storing computer instructions for executing a method for obtaining an antibody sequence, comprising:

• performing Multiple Sequence Alignment (MSA) on an antigen sequence and an initial antibody sequence respectively to obtain an antigen MSA sequence and an antibody MSA sequence;
• concatenating the antigen MSA sequence and the antibody MSA sequence, and obtaining first features of amino acids at different sequence positions in a concatenated sequence according to respective attribute features of the amino acids in the concatenated sequence, the antigen MSA sequence and the antibody MSA sequence;
• constructing a graph according to connectivity relationships among amino acids in a reference antigen-antibody complex, and obtaining second features of the amino acids at different 3D coordinates in the reference antigen-antibody complex according to respective attribute features of the amino acids in the graph;
• fusing the first features of amino acids at different sequence positions with the second features of amino acids at 3D coordinates corresponding to the different sequence positions, and obtaining probability information of each of the amino acids at different positions in the antibody sequence according to fused features;
• and
• obtaining a target antibody sequence according to the amino acids and their probability information at different positions in the antibody sequence.