Spatial binding of imaging data from multiple modalities

A system comprising:

• a controller having at least one processor and at least one non-transitory, tangible memory on which instructions are recorded for a method of spatially binding imaging data, execution of the instructions by the processor causing the controller to:
• receive a first imaging dataset of an eye from a first modality and a second imaging dataset of the eye from a second modality, the first modality being multispectral imaging, and the second modality being optical coherence tomography;
• select at least one region of interest in the first imaging dataset;
• extract a first feature set from the at least one region of interest, via a first neural network;
• extract a second feature set from the second imaging dataset, via a second neural network;
• generate feature pairs by matching a respective datapoint in the first feature set with the respective datapoint in the second feature set;
• and
• determine a coordinate transformation between the feature pairs and generate at least one spatially bound image of the eye based in part on the coordinate transformation.