Dna based sensors

Abstract

Provided is a nanoparticle comprising: a DNA scaffold comprising an attached dye, an attached functional moiety, or a combination thereof. In some embodiments, the DNA scaffold comprises a plurality of DNA oligonucleotides, wherein each oligonucleotide is independently optionally attached to a dye and/or a functional moiety. Provided is a method of cell voltage sensing at a target site comprising providing the nanoparticle of any one of the preceding embodiments at the target site; and monitoring cell voltage at the target site. Also provided is a method of fluorescence or absorbance imaging at a target site comprising providing the nanoparticle of any one of the preceding embodiments at the target site; and monitoring fluorescence or absorbance at the target site.

Dependencies are inferred from the claim text.