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AssigneeAcademisch Ziekenhuis Leiden (H.O.D.N. Lumc)
InventorsThomas Willem Johannes Huizinga, Reinaldus Everardus Maria Toes, Leendert Adrianus Trouw, Hans Ulrich Scherer
Estimating the term…
Means and methods for determining whether an individual that does not have rheumatoid arthritis, AAV or Sjögren syndrome at the moment of sampling is at risk of developing the disease, the method comprising determining whether an antibody-containing sample of the individual comprises an autoantibody associated with the disease that comprises an N-linked glycosylation at one or more positions in a Fab-portion of the antibody, the method further comprising determining the risk of the individual for developing the disease. The disease is preferably rheumatoid arthritis.
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A kit of parts useful in the detection of an autoantibody associated with rheumatoid arthritis (RA), Sjögren syndrome or anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in a sample, the kit comprising:
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A kit of parts useful in detecting an autoantibody associated with rheumatoid arthritis (RA), Sjögren syndrome, or anti-neutrophile cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in a sample, the kit comprising:
Dependencies are inferred from the claim text.