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US 2025/0093345 A1Published application

Optical biomodule for detection of diseases at an early onset

OwnerMohammad A. Mazedinventor

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Abstract

An optical biomodule for detecting a disease specific biomarker(s) at an early stage, utilizing enhanced fluorescence emission (due to integration of three-dimensional (3-D) structures in a fluidic container) upon chemical binding/coupling of a disease specific biomarker(s) with its corresponding disease specific biomarker binder(s)-coupled with a fluorophore(s) positioned horizontally within a geometrical area (that includes a center region or a middle region) is disclosed. Furthermore, a corresponding disease specific biomarker binder(s) may include an amplifying chemical structure/sequence. The three-dimensional (3-D) structure(s) may be coupled with an optical resonator and/or a photonic crystal (PC) and/or a metamaterial and/or a metamaterial of Epsilon-Near-Zero (ENZ) of a suitable wavelength range.

Claims75

Dependent claims

Claim 1An optical biomodule · 321 words16 dependent Claim 18An optical biomodule · 364 words13 dependent Claim 32An optical biomodule · 339 words10 dependent Claim 43An optical biomodule · 340 words11 dependent Claim 55An optical biomodule · 345 words10 dependent Claim 66An optical biomodule · 421 words4 dependent Claim 71An optical biomodule · 422 words4 dependent

An optical biomodule comprising:

(a) a fluidic container;
wherein the fluidic container comprises one or more (i) materials or (ii) first metamaterials,
wherein the fluidic container further comprises a first biomarker binder and/or a second biomarker binder,
wherein the first biomarker binder comprises one or more segments,
wherein the second biomarker binder comprises one or more segments,
wherein the first biomarker binder is coupled with one or more first fluorophores,
wherein the second biomarker binder is coupled with one or more second fluorophores,
wherein the first biomarker binder binds or couples with a biomarker,
wherein the second biomarker binder binds or couples with the biomarker,
wherein the fluidic container further comprises a plurality of three-dimensional (3-D) structures,
wherein the three-dimensional (3-D) structures are spaced or arranged in a one-dimensional (1-D) array or in a two-dimensional (2-D) array,
wherein a pitch or a duty cycle of the one-dimensional (1-D) array or the two-dimensional (2-D) array of the three-dimensional (3-D) structures is varied for an enhancement of a fluorescence emission or a light signal,
wherein at least (i) one of the one or more first fluorophores or (ii) one of the one or more second fluorophores is within a geometrical area in a horizontal plane, wherein the geometrical area in the horizontal plane includes a center region or a middle region in the horizontal plane, wherein the center region or the middle region in the horizontal plane is within a gap in the horizontal plane, wherein the geometrical area in the horizontal plane is defined by at least the gap in the horizontal plane, wherein the gap in the horizontal plane is defined by at least one of the one or more three-dimensional (3-D) structures,
(b) a light source for inducing the fluorescence emission or the light signal;
and
(c) a device for detecting the fluorescence emission or the light signal, wherein the device comprises (i) a photodiode or (ii) a light sensor.

13 more elements

An optical biomodule comprising:

(a) a fluidic container;
wherein the fluidic container comprises one or more (i) materials or (ii) first metamaterials,
wherein the fluidic container further comprises a first biomarker binder and/or a second biomarker binder,
wherein the first biomarker binder comprises one or more segments,
wherein the second biomarker binder comprises one or more segments,
wherein the first biomarker binder is coupled with one or more first fluorophores,
wherein the second biomarker binder is coupled with one or more second fluorophores,
wherein the first biomarker binder binds or couples with a biomarker,
wherein the second biomarker binder binds or couples with the biomarker,
wherein the first biomarker binder or the second biomarker binder comprises (i) an amplifier that includes nucleotides or (ii) a chemical structure that is coupled with a metal and/or a dielectric material, wherein the amplifier is a linear amplifier or a nonlinear amplifier,
wherein the fluidic container further comprises a plurality of three-dimensional (3-D) structures,
wherein the three-dimensional (3-D) structures are spaced or arranged in a one-dimensional (1-D) array or in a two-dimensional (2-D) array,
wherein a pitch or a duty cycle of the one-dimensional (1-D) array or the two-dimensional (2-D) array of the three-dimensional (3-D) structures is varied for an enhancement of a fluorescence emission or a light signal,
wherein at least (i) one of the one or more first fluorophores or (ii) one of the one or more second fluorophores is within a geometrical area in a horizontal plane, wherein the geometrical area in the horizontal plane includes a center region or a middle region in the horizontal plane, wherein the center region or the middle region in the horizontal plane is within a gap in the horizontal plane, wherein the geometrical area in the horizontal plane is defined by at least the gap in the horizontal plane, wherein the gap in the horizontal plane is defined by at least one of the one or more three-dimensional (3-D) structures,
(b) a light source for inducing the fluorescence emission or the light signal;
and
(c) a device for detecting the fluorescence emission or the light signal, wherein the device comprises (i) a photodiode or (ii) a light sensor.

14 more elements

An optical biomodule comprising:

(a) a fluidic container;
wherein the fluidic container comprises one or more (i) materials or (ii) first metamaterials,
wherein the fluidic container further comprises a first biomarker binder and/or a second biomarker binder,
wherein the first biomarker binder comprises one or more segments,
wherein the second biomarker binder comprises one or more segments,
wherein the first biomarker binder is coupled with one or more first fluorophores,
wherein the second biomarker binder is coupled with one or more second fluorophores,
wherein the first biomarker binder binds or couples with a biomarker,
wherein the second biomarker binder binds or couples with the biomarker,
wherein the fluidic container further comprises a plurality of three-dimensional (3-D) structures,
wherein the three-dimensional (3-D) structures are spaced or arranged in a one-dimensional (1-D) array or in a two-dimensional (2-D) array,
wherein a pitch or a duty cycle of the one-dimensional (1-D) array or the two-dimensional (2-D) array of the three-dimensional (3-D) structures is varied for an enhancement of a fluorescence emission or a light signal,
wherein at least (i) one of the one or more first fluorophores or (ii) one of the one or more second fluorophores is within a geometrical area in a horizontal plane, wherein the geometrical area in the horizontal plane includes a center region or a middle region in the horizontal plane, wherein the center region or the middle region in the horizontal plane is within a gap in the horizontal plane, wherein the geometrical area in the horizontal plane is defined by at least the gap in the horizontal plane, wherein the gap in the horizontal plane is defined by at least one of the one or more three-dimensional (3-D) structures,
wherein at least one of the three-dimensional (3-D) structures is coupled with an optical resonator,
(b) a light source or light sources for inducing the fluorescence emission or the light signal;
and
(c) a device for detecting the fluorescence emission or the light signal, wherein the device comprises (i) a photodiode or (ii) a light sensor.

14 more elements

An optical biomodule comprising:

(a) a fluidic container;
wherein the fluidic container comprises one or more (i) materials or (ii) first metamaterials,
wherein the fluidic container further comprises a first biomarker binder and/or a second biomarker binder,
wherein the first biomarker binder comprises one or more segments,
wherein the second biomarker binder comprises one or more segments,
wherein the first biomarker binder is coupled with one or more first fluorophores,
wherein the second biomarker binder is coupled with one or more second fluorophores,
wherein the first biomarker binder binds or couples with a biomarker,
wherein the second biomarker binder binds or couples with the biomarker,
wherein the fluidic container further comprises a plurality of three-dimensional (3-D) structures,
wherein the three-dimensional (3-D) structures are spaced or arranged in a one-dimensional (1-D) array or in a two-dimensional (2-D) array,
wherein a pitch or a duty cycle of the one-dimensional (1-D) array or the two-dimensional (2-D) array of the three-dimensional (3-D) structures is varied for an enhancement of a fluorescence emission or a light signal,
wherein at least (i) one of the one or more first fluorophores or (ii) one of the one or more second fluorophores is within a geometrical area in a horizontal plane, wherein the geometrical area in the horizontal plane includes a center region or a middle region in the horizontal plane, wherein the center region or the middle region in the horizontal plane is within a gap in the horizontal plane, wherein the geometrical area in the horizontal plane is defined by at least the gap in the horizontal plane, wherein the gap in the horizontal plane is defined by at least one of the one or more three-dimensional (3-D) structures,
wherein at least one of the three-dimensional (3-D) structures is coupled with a photonic crystal (PC),
(b) a light source or light sources for inducing the fluorescence emission or the light signal;
and
(c) a device for detecting the fluorescence emission or the light signal, wherein the device comprises (i) a photodiode or (ii) a light sensor.

14 more elements

An optical biomodule comprising:

(a) a fluidic container;
wherein the fluidic container comprises one or more (i) materials or (ii) first metamaterials,
wherein the fluidic container further comprises a first biomarker binder and/or a second biomarker binder,
wherein the first biomarker binder comprises one or more segments,
wherein the second biomarker binder comprises one or more segments,
wherein the first biomarker binder is coupled with one or more first fluorophores,
wherein the second biomarker binder is coupled with one or more second fluorophores,
wherein the first biomarker binder binds or couples with a biomarker,
wherein the second biomarker binder binds or couples with the biomarker,
wherein the fluidic container further comprises a plurality of three-dimensional (3-D) structures,
wherein the three-dimensional (3-D) structures are spaced or arranged in a one-dimensional (1-D) array or in a two-dimensional (2-D) array,
wherein a pitch or a duty cycle of the one-dimensional (1-D) array or the two-dimensional (2-D) array of the three-dimensional (3-D) structures is varied for an enhancement of a fluorescence emission or a light signal,
wherein at least (i) one of the one or more first fluorophores or (ii) one of the one or more second fluorophores is within a geometrical area in a horizontal plane, wherein the geometrical area in the horizontal plane includes a center region or a middle region in the horizontal plane, wherein the center region or the middle region in the horizontal plane is within a gap in the horizontal plane, wherein the geometrical area in the horizontal plane is defined by at least the gap in the horizontal plane, wherein the gap in the horizontal plane is defined by at least one of the one or more three-dimensional (3-D) structures,
wherein at least one of the three-dimensional (3-D) structures is coupled with a second metamaterial, wherein the second metamaterial is a hyperbolic metamaterial (HMM),
(b) a light source for inducing the fluorescence emission or the light signal;
and
(c) a device for detecting the fluorescence emission or the light signal, wherein the device comprises (i) a photodiode or (ii) a light sensor.

14 more elements

An optical biomodule comprising:

(a) a fluidic container;
wherein the fluidic container comprises one or more (i) materials or (ii) first metamaterials,
wherein the fluidic container further comprises a first biomarker binder and/or a second biomarker binder,
wherein the first biomarker binder comprises one or more segments,
wherein the second biomarker binder comprises one or more segments,
wherein the first biomarker binder is coupled with one or more first fluorophores,
wherein the second biomarker binder is coupled with one or more second fluorophores,
wherein the first biomarker binder binds or couples with a biomarker,
wherein the second biomarker binder binds or couples with the biomarker,
wherein the first biomarker binder or the second biomarker binder comprises (i) an amplifier that includes nucleotides or (ii) a chemical structure that is coupled with a metal and/or a dielectric material, wherein the amplifier is a linear amplifier or a nonlinear amplifier,
wherein the fluidic container further comprises a plurality of three-dimensional (3-D) structures,
wherein the three-dimensional (3-D) structures are spaced or arranged in a one-dimensional (1-D) array or in a two-dimensional (2-D) array,
wherein a pitch or a duty cycle of the one-dimensional (1-D) array or the two-dimensional (2-D) array of the three-dimensional (3-D) structures is varied for an enhancement of a fluorescence emission or a light signal,
wherein at least (i) one of the one or more first fluorophores or (ii) one of the one or more second fluorophores is within a geometrical area in a horizontal plane, wherein the geometrical area in the horizontal plane includes a center region or a middle region in the horizontal plane, wherein the center region or the middle region in the horizontal plane is within a gap in the horizontal plane, wherein the geometrical area in the horizontal plane is defined by at least the gap in the horizontal plane, wherein the gap in the horizontal plane is defined by at least one of the one or more three-dimensional (3-D) structures,
or wherein at least (i) one of the one or more first fluorophores or (ii) one of the one or more second fluorophores is coupled with a near field lens, wherein the near field lens comprises a metal thin-film,
wherein at least one of the three-dimensional (3-D) structures is coupled with an optical resonator,
(b) a light source or light sources for inducing the fluorescence emission or the light signal;
and
(c) a device for detecting the fluorescence emission or the light signal, wherein the device comprises (i) a photodiode or (ii) a light sensor.

16 more elements

An optical biomodule comprising:

(a) a fluidic container;
wherein the fluidic container comprises one or more (i) materials or (ii) first metamaterials,
wherein the fluidic container further comprises a first biomarker binder and/or a second biomarker binder,
wherein the first biomarker binder comprises one or more segments,
wherein the second biomarker binder comprises one or more segments,
wherein the first biomarker binder is coupled with one or more first fluorophores,
wherein the second biomarker binder is coupled with one or more second fluorophores,
wherein the first biomarker binder binds or couples with a biomarker,
wherein the second biomarker binder binds or couples with the biomarker,
wherein the first biomarker binder or the second biomarker binder comprises (i) an amplifier that includes nucleotides or (ii) a chemical structure that is coupled with a metal and/or a dielectric material, wherein the amplifier is a linear amplifier or a nonlinear amplifier,
wherein the fluidic container further comprises a plurality of three-dimensional (3-D) structures,
wherein the three-dimensional (3-D) structures are spaced or arranged in a one-dimensional (1-D) array or in a two-dimensional (2-D) array,
wherein a pitch or a duty cycle of the one-dimensional (1-D) array or the two-dimensional (2-D) array of the three-dimensional (3-D) structures is varied for an enhancement of a fluorescence emission or a light signal,
wherein at least (i) one of the one or more first fluorophores or (ii) one of the one or more second fluorophores is within a geometrical area in a horizontal plane, wherein the geometrical area in the horizontal plane includes a center region or a middle region in the horizontal plane, wherein the center region or the middle region in the horizontal plane is within a gap in the horizontal plane, wherein the geometrical area in the horizontal plane is defined by at least the gap in the horizontal plane, wherein the gap in the horizontal plane is defined by at least one of the one or more three-dimensional (3-D) structures,
or wherein at least (i) one of the one or more first fluorophores or (ii) one of the one or more second fluorophores is coupled with a near field lens, wherein the near field lens comprises a metal thin-film,
wherein at least one of the three-dimensional (3-D) structures is coupled with a photonic crystal (PC),
(b) a light source or light sources for inducing the fluorescence emission or the light signal;
and
(c) a device for detecting the fluorescence emission or the light signal, wherein the device comprises (i) a photodiode or (ii) a light sensor.

16 more elements

Dependencies are inferred from the claim text.

Facts

Application: 18/831,208Filed 14 Sep 2024
Priority: 28 Sep 2019
Published: 20 Mar 2025
Term ends: Not estimatedThe source records don’t support an estimate.

Classification13 codes

G01N 33/5436
With an insoluble carrier for immobilising immunochemicals: with ligand physically entrapped within the solid phase
G01N 21/03
Arrangements or apparatus for facilitating the optical investigation: cuvette constructions
G01N 21/6428
Fluorescence; Phosphorescence: measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g.…
G01N 33/54386
Apparatus specially adapted for solid-phase testing: analytical elements

Family

Application16/602,404Continuation in part · filed 28 Sep 2019
Application16/602,966Continuation in part · filed 6 Jan 2020
Application63/259,026Us provisional application · filed 15 Jun 2021
Application17/803,387Continuation in part · filed 15 Jun 2022
Application63/630,475Us provisional application · filed 1 Feb 2024
Application18/831,208Continuation in part
US 11,320,588 B1Related patent
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US 2022/0003676 A1Published application
US 2025/0093345 A1This patent

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