US 2025/0093254 A1 · SYSTEMS AND METHODS FOR SPECTROSCOPIC MEASUREMENTS OF INHOMOGENEOUS MIXTURES

Abstract

Methods and systems are described for performing spectroscopic measurement of at least one analyte of interest in an inhomogeneous sample using a spectroscopic system. This generally involves generating and aiming an illumination beam which forms a focal region having focal region size S upon a surface or within a volume of the sample where there is relative motion between the sample and the focal region at a relative speed V; selecting a desired ratio between an exposure time E for a detector of the spectroscopic system and a transit time T for a particle of the at least one analyte of interest to traverse the focal region; acquiring one or more spectral data sets corresponding to spectra for a region of the sample within the focal region; and analyzing the one or more spectral data sets to generate one or more corresponding analytical results.

Claims20

Dependent claims

A method for performing spectroscopic measurement of at least one analyte of interest in an inhomogeneous sample using a spectroscopic system, wherein the method comprises:

generating and aiming an illumination beam which forms a focal region upon a surface of the sample or within a volume of the sample where there is relative motion between the sample and the focal region at a relative speed;
selecting a desired ratio between an exposure time for a detector of the spectroscopic system and a transit time for a particle of the at least one analyte of interest to traverse the focal region;
acquiring one or more spectral data sets corresponding to one or more spectra for a region of the sample within the focal region;
and
analyzing the one or more spectral data sets to generate one or more corresponding analytical results.

2 more elements

A spectroscopic system for performing spectroscopic measurement of at least one analyte of interest in an inhomogeneous sample, wherein the system comprises:

a light source for generating an illumination beam;
a sample measurement apparatus that is optically coupled to the light source for transmitting the illumination beam to form a focal region upon a surface of the sample or within a volume of the sample where the sample and the focal region move relative to one another at a relative speed;
a spectrometer that is optically coupled to the sample measurement apparatus for receiving light that is scattered, reflected, or emitted from the sample in response to the illumination beam;
and
a computing device that includes at least one processor that is configured to execute software instructions causing the computing device to perform the spectroscopic measurement by:
selecting a desired ratio between an exposure time for a detector of the spectrometer and a transit time for a particle of the at least one analyte of interest to traverse the focal region;
acquiring one or more spectral data sets for a region of the sample within the focal region;
and
analyzing the one or more spectral data sets to generate one or more corresponding analytical results.

6 more elements

Dependencies are inferred from the claim text.

Systems and methods for spectroscopic measurements of inhomogeneous mixtures

Life of this patent

Systems and methods for spectroscopic measurements of inhomogeneous mixtures

Life of this patent

Abstract

Claims20