Methods and systems for ion mobility spectrometry

A method for ion mobility spectrometry, the method comprising:

• introducing an ionized sample and an ionized calibrant in a drift chamber;
• generating, by an ion detector, a drift signal in response to detecting drifted ions at a predetermined position along the drift chamber;
• generating, by a thermal sensor, a temperature signal indicative of a temperature of the drift chamber;
• and
• by processing circuitry:
• determining, based on the temperature signal, a mobility relation for a target species with respect to the ionized calibrant;
• determining, based on the drift signal, a calibrant drift time and a sample drift time;
• determining, based on the mobility relation and the calibrant drift time, a target drift time for the target species;
• and
• detecting the target species in the ionized sample by comparing the sample drift time with the target drift time.

Non-transitory computer-readable media comprising instructions that, when executed, cause processing circuitry to:

• determine, based on a drift signal received from an ion detector in response to detecting drifted ions at a predetermined position along a drift chamber, a calibrant drift time of an ionized calibrant and a sample drift time of an ionized sample in the drift chamber;
• determine, based on a temperature signal indicative of a temperature of the drift chamber received from a thermal sensor, a mobility relation for a target species with respect to the ionized calibrant;
• determine, based on the mobility relation and the calibrant drift time, a target drift time for the target species;
• and
• detect the target species in the ionized sample by comparing the sample drift time with the target drift time.