Differential output of analog memories storing nanopore measurement samples
AssigneeRoche Sequencing Solutions, Inc.
InventorsSantiago Fernandez-Gomez, Bill Maney, Hui Tian
Life of this patent
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Abstract
A nanopore measurement circuit includes a first analog memory configured to store a first electrical value corresponding to a first measurement sample of a nanopore and a second analog memory configured to store a second electrical value corresponding to a second measurement sample of the nanopore. The nanopore measurement circuit also includes a measurement circuitry configured to provide an output indicating a difference between the first electrical value of the first analog memory and the second electrical value of the second analog memory.
Claims20
A biochip, comprising:
- a plurality of nanopore cells, each nanopore cell associated with a measurement circuit configured to measure an electrical characteristic of the nanopore cell;
- a plurality of local event detectors, each local event detector comprising a circuit configured to receive an electrical measurement sample from a corresponding measurement circuit of a respective nanopore cell;
- and
- an adaptive analyzer configured to periodically receive data from the plurality of local event detectors, modify the data based on state change information related to the plurality of local event detectors, and store the modified data in a buffer for output.
A method for outputting data from a biochip including a plurality of nanopore cells, the method comprising:
- receiving data from a plurality of local event detectors, each local event detector comprising a circuit configured to receive an electrical measurement sample from a corresponding measurement circuit of a respective nanopore cell;
- modifying the data based on state change information determined by the plurality of local event detectors;
- and
- storing the modified data in a buffer for output.
A system, comprising:
- a plurality of nanopore cells, each nanopore cell comprising an electrode connected to an analog measurement circuit for measuring an electrical characteristic of the nanopore cell and a local event detector circuit configured to receive an electrical measurement sample from the analog measurement circuit;
- at least one adaptive analyzer circuit configured to:
- periodically receive data from a plurality of local event detector circuits, wherein the data comprises at least one measurement value of an electrical measurement sample collected during a measurement period,
- modify the data based on state change information, and
- store the modified data in a buffer for output;
- and
- an application specific integrated circuit (ASIC) or field programmable gate array (FPGA) configured to receive the modified data from the buffer.
Dependencies are inferred from the claim text.