Back to results
US 2025/0085219 A1Published application
Minimization of Noise in Optical Data Capture for Liquids By Light Modulation Means
AssigneeAirware, Inc.
InventorsThomas G. Campbell, Jacob Y. Wong
Life of this patent
Estimating the term…
Abstract
A process and sensor system with particular control of polarization of the interrogating light beams useful for determining a concentration of a targeted molecule M (such as glucose) within a given time period in a liquid sampling matrix through use of a Direct Infrared Laser Absorption Spectroscopy Technique.
Claims17
A process for quantifying a concentration of a targeted molecule M in a liquid sample matrix through use of a sensor system comprised of electronic components, optical elements and software modules, comprising the steps of:
- detecting, by at least one detector, a pulsed source signal, a pulsed interference signal, and a pulsed reference signal after they penetrate into a sample volume of the liquid sample matrix;
- and
- obtaining, using signal processing,
- i) a first average ratio value for a first preselected period of time from the pulsed source signal and the pulsed reference signal emerging from the sample volume and
- ii) a second average ratio value for a second preselected period of time from the pulsed interference signal and pulsed reference signal;
- and
- calculating, using electronics, the concentration of the targeted molecule M in the liquid sample matrix based on the first average ratio value for the first preselected period of time and a calibration curve validated using the second average ratio value for the second preselected period of time,
- wherein a signal source emits radiation at a signal wavelength which is within a first absorption band of the targeted molecule M, an interference source emits radiation at an interference wavelength which is within a second absorption band of said at least one interfering molecule MJ, and a reference beam emits radiation at a reference wavelength which is neutral and is not within either the first absorption band or the second absorption band;
- and
- wherein the pulsed source signal is circularly polarized.
7 more elements
A system for quantifying a concentration of a targeted molecule M in a liquid sample matrix through use of a sensor system comprised of electronic components, optical elements and software modules, comprising:
- a coherent laser signal source;
- means for circularly polarizing a reference signal from the coherent laser signal source;
- a coherent laser reference source;
- a coherent laser interference source;
- means for configuring pulsed radiation from the coherent laser source, the coherent laser reference source and the coherent laser interference source into a pulsed beam;
- at least one detector configured to detect a pulsed source signal, a pulsed interference signal, and a pulsed reference signal after they penetrate into a sample volume of the liquid sample matrix;
- signal processing for obtaining:
- i) a first average ratio value for a first preselected period of time from the pulsed source signal and the pulsed reference signal emerging from the sample volume and
- ii) a second average ratio value for a second preselected period of time from the pulsed interference signal and pulsed reference signal;
- and
- electronics for calculating the concentration of the targeted molecule M in the liquid sample matrix based on the first average ratio value for the first preselected period of time and a calibration curve validated using the second average ratio value for the second preselected period of time,
- wherein the coherent signal source emits radiation at a signal wavelength which is within a first absorption band of the targeted molecule M, the coherent interference source emits radiation at an interference wavelength which is within a second absorption band of said at least one interfering molecule MJ, and the coherent reference beam emits radiation at a reference wavelength which is neutral and is not within either the first absorption band or the second absorption band.
9 more elements
A system for quantifying a concentration of a targeted molecule M in a liquid sample matrix through use of a sensor system comprised of electronic components, optical elements and software modules, comprising:
- an electronics front end comprising at least one signal generator, at least one laser driver, at least one TE cooler controller and at least one temperature sensor configured with a laser signal source, a laser reference source, a laser interference source, a combiner system and means for circularly polarizing at least a reference signal from the laser signal source;
- and
- an electronics back end comprising:
- (1) at least one detector configured to detect a pulsed source signal, a pulsed interference signal, and a pulsed reference signal after they penetrate into a sample volume of the liquid sample matrix;
- (2) signal processing for obtaining i) a first average ratio value for a first preselected period of time from the pulsed source signal and the pulsed reference signal emerging from the sample volume and ii) a second average ratio value for a second preselected period of time from the pulsed interference signal and pulsed reference signal;
- and
- (3) electronics for calculating the concentration of the targeted molecule M in the liquid sample matrix based on the first average ratio value for the first preselected period of time and a calibration curve validated using the second average ratio value for the second preselected period of time,
- wherein the laser signal source emits radiation at a signal wavelength which is within a first absorption band of the targeted molecule M, the laser interference source emits radiation at an interference wavelength which is within a second absorption band of said at least one interfering molecule MJ, and the laser reference beam emits radiation at a reference wavelength which is neutral and is not within either the first absorption band or the second absorption band.
5 more elements
Dependencies are inferred from the claim text.