Off-chip pressure-controlled centrifugal microfluidic fractionation

A microfluidic chip controller comprising:

• a body having a coupling for mounting to a centrifuge while permitting concurrent mounting of a microfluidic chip to the centrifuge, so that the body and chip are rotatable by the centrifuge;
• the body having a first opening to a first pressurized fluid supply;
• a first pressurized fluid supply line having first and second ends, the first end for fluid communication with the first opening, and the second end adapted for fluid communication with a first port of the chip;
• a flow control device for selectively controlling a supplied pressure to the first port;
• and
• an electrical circuit for controlling the flow control device,
• whereby the microfluidic chip controller mounted with the chip to the centrifuge, with the first supply line connected to the first port of the chip, allows for controlled delivery of pressurized fluid into the chip during centrifugation.