Method of predicting survival rates for cancer patients

A method for generating a biomarker signature for a subject with cancer, the method comprising:

• generating training data from a plurality of subjects who have had cancer, the training data comprising gene expression data for a plurality of genes for each of the plurality of subjects;
• calculating both an intra-tumour heterogeneity measure and an inter-tumour heterogeneity measure for each gene in the plurality of genes based on the gene expression data;
• and
• applying a heterogeneity filter to select genes having both an intra-tumour heterogeneity below an intra-tumour heterogeneity threshold and an inter-tumour heterogeneity above an inter-tumour heterogeneity threshold;
• wherein the biomarker signature comprises at least some of the selected genes.