Methods of treating eosinophilic colitis

A method of treating inflammatory bowel disease (IBD) with high colonic eosinophilia in an individual, the method comprising

• a) assaying a colonic tissue sample obtained from said individual for expression of at least one gene, or at least two genes, or at least two genes, or at least two genes, or at least three genes, or at least four genes, or at least five genes, or at least six genes, or at least seven genes, or at least eight genes, or at least nine genes, or at least ten genes, or at least 11 genes, or at least 12 genes, or at least 13 genes, or at least 14 genes, or at least 15 genes, or at least 16 genes, or all genes of the EoC transcriptome of Table 11;
• b) calculating an EoC-IBD differential score;
• c) selecting a sample that exhibits an EoC-IBD differential score indicative of IBD;
• and
• d) administering a therapy for IBD to the individual whose sample was selected in (c).

A method of diagnosing an individual with active EoC, said method comprising

• a) assaying a tissue sample obtained from a colon of said individual for expression of at least one gene of an EoC transcriptome gene set;
• b) calculating an EoC score based on said expression of EoC transcriptome gene set;
• c) selecting a tissue sample that exhibits an EoC score indicative of active EoC;
• and
• d) diagnosing the individual whose tissue sample was selected in (c) with active EoC.

A method of diagnosing inflammatory bowel disease (IBD) with high colonic eosinophilia in an individual, the method comprising

• a) assaying a colonic tissue sample obtained from said individual for expression of at least one gene, or at least two genes, or at least two genes, or at least two genes, or at least three genes, or at least four genes, or at least five genes, or at least six genes, or at least seven genes, or at least eight genes, or at least nine genes, or at least ten genes, or at least 11 genes, or at least 12 genes, or at least 13 genes, or at least 14 genes, or at least 15 genes, or at least 16 genes, or all genes of the EoC transcriptome as listed in Table 11;
• b) calculating an EoC-IBD differential score;
• c) selecting a sample that exhibits an EoC-IBD differential score indicative of IBD;
• and
• d) diagnosing the individual whose sample was selected in (c) with IBD.