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US 2025/0084474 A1Published application
Optics Collection and Detection System and Method
AssigneePacific Biosciences of California, Inc.
InventorsAdrian FEHR, Nathaniel Joseph MCCAFFREY, Stephen TURNER
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Abstract
Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.
Claims21
1-37. (canceled)
An integrated device for distinguishing multiple fluorophores from an array of optical sources over time, the device comprising:
- an array of elements, each element comprising:
- a top layer comprising an optical source that emits two or more fluorescent signals, each fluorescent signal having a different rate of signal decay;
- a middle layer;
- and
- a bottom layer comprising a detector having a single pixel;
- wherein the middle layer transfers light from the top layer to a bottom layer;
- wherein the pixel is configured to measure photonic emission lifetime of each of the two or more different fluorescent signals to distinguish the identity of each of the fluorescent signals.
4 more elements
A method of distinguishing multiple fluorophores from an array of optical sources over time, the method comprising:
- providing a device comprising an array of elements, each element comprising:
- a top layer comprising an optical source that emits two or more fluorescent signals, each fluorescent signal having a different rate of signal decay;
- a middle layer;
- and
- a bottom layer comprising a detector having a single pixel;
- wherein the middle layer transfers light from the top layer to a bottom layer;
- and
- measuring photonic emission lifetime of each of the two or more different fluorescent signals to distinguish the identity of each of the fluorescent signals.
5 more elements
Dependencies are inferred from the claim text.