Recruitment of dna polymerase for templated editing

A method of modifying a target nucleic acid, the method comprising:

• contacting the target nucleic acid with:
• (a) a sequence-specific DNA binding protein that binds to a site on a target nucleic acid, wherein the sequence-specific DNA binding protein is from a CRISPR-Cas effector protein;
• (b) a DNA endonuclease having nickase or nuclease activity that introduces a single strand nick or a double strand break in the target nucleic acid;
• (c) an RNA:
• DNA hybrid guide comprising an RNA guide nucleic acid and a DNA encoded repair template, wherein the DNA encoded repair template is linked to the RNA guide nucleic acid, thereby guiding the DNA encoded repair template to the target nucleic acid;
• and
• (d) a DNA-dependent DNA polymerase that initiates strand synthesis copying genetic information from the DNA encoded repair template to the target nucleic acid, wherein the DNA-dependent DNA polymerase is recruited to the sequence-specific DNA binding protein, thereby modifying the target nucleic acid.