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US 2025/0084380 A1Published application
Artificial brain tissue
OwnerDavid L. Kaplan, William Cantley +5inventors
InventorsDavid L. Kaplan, William Cantley, Volha Liaudanskaya, Disha Sood, Yu-Ting Dingle, William Collins, Fiorenzo G. Omenetto
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Abstract
The present invention provides, among other things, powerful new tools for therapeutic and research uses in the central and/or peripheral nervous system. The present invention provides, inter alia, compositions including a plurality of human nerve cells, a plurality of glial cells, and silk fibroin, as well as methods for making and using such compositions.
Claims20
A composition comprising a porous, three-dimensional silk fibroin matrix, comprising:
- a plurality of pores;
- a conduit within the porous three-dimensional silk fibroin matrix sufficient to support flow of at least one fluid;
- a plurality of brain microvascular endothelial cells;
- and
- at least one extracellular matrix (ECM) agent.
2 more elements
A method comprising:
- associating one or more active agents with a porous, three-dimensional silk fibroin matrix, the porous, three-dimensional silk fibroin matrix comprising:
- a plurality of pores,
- a conduit within the porous, three-dimensional silk fibroin matrix sufficient to support flow of at least one fluid,
- a plurality of brain microvascular endothelial cells, and
- at least one extracellular matrix (ECM) agent;
- and
- determining if the one or more active agents modulates a production of the porous, three-dimensional silk fibroin matrix of at least one neurotransmitter.
4 more elements
Dependencies are inferred from the claim text.