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US 2025/0084188 A1Published application
Anti-chitinase-3-like protein 1 antibody
OwnerJin Tae HONG, Joo Eon LEE +2inventors
InventorsJin Tae HONG, Joo Eon LEE, Dae Young KIM, So Ra PARK
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Abstract
An anti-chitinase-3-like protein 1 antibody or antigen-binding fragment thereof of the present invention comprises a light chain variable region comprising CDRs of table 1 and a heavy chain variable region comprising CDRs of table 2. The antibody is capable of specifically binding to chitinase-3-like protein 1 (CHI3L1) and thus can be used for the prevention or treatment of a CHI3L1-associated disease, or for the diagnosis of the disease.
Claims16
An anti-chitinase-3-like protein 1 antibody or an antigen-binding fragment thereof, comprising:
- a light chain variable region including CDR1 of SEQ ID NO:
- 1, CDR2 of SEQ ID NO:
- 2, and CDR3 of SEQ ID NO:
- 3, and a heavy chain variable region including CDR1 of SEQ ID NO:
- 31, CDR2 of SEQ ID NO:
- 32, and CDR3 of SEQ ID NO:
- 33;
- a light chain variable region including CDR1 of SEQ ID NO:
- 4, CDR2 of SEQ ID NO:
- 5, and CDR3 of SEQ ID NO:
- 6, and a heavy chain variable region including CDR1 of SEQ ID NO:
- 34, CDR2 of SEQ ID NO:
- 35, and CDR3 of SEQ ID NO:
- 36;
- a light chain variable region including CDR1 of SEQ ID NO:
- 7, CDR2 of SEQ ID NO:
- 8, and CDR3 of SEQ ID NO:
- 9, and a heavy chain variable region including CDR1 of SEQ ID NO:
- 37, CDR2 of SEQ ID NO:
- 38, and CDR3 of SEQ ID NO:
- 39;
- a light chain variable region including CDR1 of SEQ ID NO:
- 10, CDR2 of SEQ ID NO:
- 11, and CDR3 of SEQ ID NO:
- 12, and a heavy chain variable region including CDR1 of SEQ ID NO:
- 40, CDR2 of SEQ ID NO:
- 41, and CDR3 of SEQ ID NO:
- 42;
- a light chain variable region including CDR1 of SEQ ID NO:
- 13, CDR2 of SEQ ID NO:
- 14, and CDR3 of SEQ ID NO:
- 15, and a heavy chain variable region including CDR1 of SEQ ID NO:
- 43, CDR2 of SEQ ID NO:
- 44, and CDR3 of SEQ ID NO:
- 45;
- a light chain variable region including CDR1 of SEQ ID NO:
- 16, CDR2 of SEQ ID NO:
- 17, and CDR3 of SEQ ID NO:
- 18, and a heavy chain variable region including CDR1 of SEQ ID NO:
- 46, CDR2 of SEQ ID NO:
- 47, and CDR3 of SEQ ID NO:
- 48;
- a light chain variable region including CDR1 of SEQ ID NO:
- 19, CDR2 of SEQ ID NO:
- 20, and CDR3 of SEQ ID NO:
- 21, and a heavy chain variable region including CDR1 of SEQ ID NO:
- 49, CDR2 of SEQ ID NO:
- 50, and CDR3 of SEQ ID NO:
- 51;
- a light chain variable region including CDR1 of SEQ ID NO:
- 22, CDR2 of SEQ ID NO:
- 23, and CDR3 of SEQ ID NO:
- 24, and a heavy chain variable region including CDR1 of SEQ ID NO:
- 52, CDR2 of SEQ ID NO:
- 53, and CDR3 of SEQ ID NO:
- 54;
- a light chain variable region including CDR1 of SEQ ID NO:
- 25, CDR2 of SEQ ID NO:
- 26, and CDR3 of SEQ ID NO:
- 27, and a heavy chain variable region including CDR1 of SEQ ID NO:
- 55, CDR2 of SEQ ID NO:
- 56, and CDR3 of SEQ ID NO:
- 57;
- or
- a light chain variable region including CDR1 of SEQ ID NO:
- 28, CDR2 of SEQ ID NO:
- 29, and CDR3 of SEQ ID NO:
- 30, and a heavy chain variable region including CDR1 of SEQ ID NO:
- 58, CDR2 of SEQ ID NO:
- 59, and CDR3 of SEQ ID NO:
- 60.
68 more elements
Dependencies are inferred from the claim text.