Anti-cd39 antibodies and use thereof

An anti-CD39 antibody that specifically binds to human CD39, comprising

• (a) a heavy chain variable region comprising a complementarity determining region 1 (H1) having an amino acid sequence comprising SEQ ID NO:
• 10, a complementarity determining region 2 (H2) having an amino acid sequence comprising SEQ ID NO:
• 11, and a complementarity determining region 3 (H3) having an amino acid sequence comprising SEQ ID NO:
• 12;
• and a light chain variable region comprising a complementarity determining region 1 (L1) having an amino acid sequence comprising SEQ ID NO:
• 14, a complementarity determining region 2 (L2) having an amino acid sequence comprising SEQ ID NO:
• 15, and a complementarity determining region 3 (L3) having an amino acid sequence comprising ID NO:
• 16;
• (b) a heavy chain variable region comprising an H1 having an amino acid sequence comprising SEQ ID NO:
• 18, an H2 having an amino acid sequence comprising SEQ ID NO:
• 19, and an H3 having an amino acid sequence comprising SEQ ID NO:
• 20;
• and a light chain variable region comprising an L1 having an amino acid sequence comprising SEQ ID NO:
• 22, SEQ ID NO:
• 23, or SEQ ID NO:
• 24, an L2 having an amino acid sequence comprising SEQ ID NO:
• 25, and an L3 having an amino acid sequence comprising SEQ ID NO:
• 26;
• or
• (c) a heavy chain variable region comprising an H1 having an amino acid sequence comprising SEQ ID NO:
• 28, an H2 having an amino acid sequence comprising SEQ ID NO:
• 29, and an H3 having an amino acid sequence comprising SEQ ID NO:
• 30;
• and a light chain variable region comprising an L1 having an amino acid sequence comprising SEQ ID NO:
• 32, an L2 having an amino acid sequence comprising SEQ ID NO:
• 33, and an L3 having an amino acid sequence comprising SEQ ID NO:
• 34.