Fc binding fragments comprising a cd137 antigen-binding site
AssigneeInvox Pharma Limited
InventorsMatthew Lakins, Jose Munoz-Olaya, Sarka Pechouckova, Mihriban Tuna
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Abstract
The invention relates to specific binding members that bind CD137. The specific binding members comprise a CD137 antigen-binding site located in a constant domain of the specific binding member and find application in the treatment of cancer and infectious diseases, for example.
Claims24
A specific binding member that binds CD137 and comprises a CD137 antigen-binding site located in a CH3 domain of the specific binding member, the CD137 antigen-binding site comprising a first sequence located in the AB structural loop of the CH3 domain, wherein said first sequence comprises the sequence PPY (SEQ ID NO:
- 10).
-21. (canceled)
Dependencies are inferred from the claim text.