Back to results
US 2025/0084161 A1Published application
Anti p2x7 receptor antibodies and fragments thereof
AssigneeBiosceptre (Aust) Pty Ltd
InventorsJulian Alexander Barden, Neil Brewis, Philip Jones, Steven Grant
Life of this patent
Estimating the term…
Abstract
The invention relates to an antigen binding site for binding to a P2X7 receptor, the antigen binding site being defined by general formula 1: FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4
Claims23
An antigen binding site for binding to a P2X7 receptor, the antigen binding site being defined by general formula 1:
- FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4
- wherein:
- FR1, FR2, FR3 and FR4 are each framework regions;
- CDR1, CDR2 and CDR3 are each complementarity determining regions;
- wherein:
- CDR1 has a sequence selected from the group
- consisting of:
- DNEPMG, RNHDMG, SGYAMA, GMYNMS,
- PASNMS, GSYAMA, GAYAMS, DGYNMS, TYDMAW,
- QEYGMG, ARYPMA, SSYAMA, AKYPMV, SSYAMS,
- DNVEMS and PMKDMG.
8 more elements
An antigen binding site for binding to a P2X7 receptor, the antigen binding site being defined by general formula 2:
- FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4
- wherein:
- FR1, FR2, FR3 and FR4 are each framework regions;
- CDR1, CDR2 and CDR3 are each complementarity determining regions;
- wherein:
- CDR2 has a sequence selected from the
- group consisting of:
- SIADSGNHTYYADSVKG,
- AISGSGGSTYYADSVKG, TILSDGSRTYYADSVKG,
- SINATGGRTYYADSVKG, SITASGYRTYYADSVKG,
- TISTSGSSTYYADSVKG, TINGSGLATYYADSVKG,
- SITANGNSTYYADSVKG, SIAAAGSRTYYADSVKG,
- SITPSGDKTYYADSVKG, SIDGGGLQTYYADSVKG,
- TIDGNGLITYYADSVKG, SIGPGGARTYYADSVKG,
- TITSDGLRTYYADSVKG, SIGSKGEDTYYADSVKG,
- AISGSGGSTYYANSVKG, AISGSGGGTYYADSVKG,
- SIGTKGEYTYYADSVKG, SIGSKGEYTYYADSVKG and
- AISGSGGGTYYANSVKG.
15 more elements
An antigen binding site for binding to a P2X7 receptor, the antigen binding site being defined by general formula 3:
- FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4
- wherein:
- FR1, FR2, FR3 and FR4 are each framework regions;
- CDR1, CDR2 and CDR3 are each complementarity determining regions;
- wherein:
- CDR3 has a sequence selected from the
- group consisting of:
- KQRGLNRYRAQFDY, EPKPMDTEFDY,
- KIKTFRNHSVQFDY, KFNGFSHRQYNFDY, KQGQISNFPRFDY,
- KVRFATSKSINFDY, KCSSCTSLNANFDY, KASYSRPYNFQFDY,
- KQRSISIRPMFDY, KVRSMSYAHFDFDY, KASAPKYFRFDY,
- KLQRYDRYTLNFDY, KPWRVYSYDRFDY, KVHTFANRSLNFDY,
- QTVNVPEPAFAY and EPSHFDRPFDY.
10 more elements
4-11. (canceled)
26-27. (canceled)
31-32. (canceled)
Dependencies are inferred from the claim text.