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US 2025/0084157 A1Published application
Antibody based reagents that specifically recognize toxic oligomeric forms of tau
AssigneeArizona Board of Regents on behalf of Arizona State University
InventorsMichael SIERKS, Huilai TIAN
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Abstract
The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomeric tau, fibrillar tau or non-disease associated forms of tau.
Claims23
A binding molecule comprising six complementarity determining regions (CDRs) having amino acid sequences NFGMH (SEQ ID NO:
- 63), IISYDASSEYYADSVKG (SEQ ID NO:
- 64), and KDGRSGSYYYGDY (SEQ ID NO:
- 65), RASQDFRNWLA (SEQ ID NO:
- 66), GASTLQN (SEQ ID NO:
- 67), and QQAHSFPPT (SEQ ID NO:
- 68), of SEQ ID NO:
- 17.
4 more elements
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Dependencies are inferred from the claim text.