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US 2025/0084151 A1Published application
Recombinant clusterin and use thereof in the treatment and prevention of disease
AssigneeBoard of Regents, The University of Texas System
InventorYong-Jian GENG
Life of this patent
Estimating the term…
Abstract
Recombinant clusterin polypeptides and compositions comprising the same are provided. In some aspects, recombinant clusterin or nucleic acids encoding the same may be used for treating and preventing an abnormality of morphology and function in a mammal with disease (e.g., cardiovascular diseases or alcoholism).
Claims26
1-33. (canceled)
A method of providing a cytoprotective effect to vascular cells in a subject having cardiovascular disease comprising administering an effective amount of a composition providing to said subject a polypeptide comprising:
- (i) a Clusterin coding sequence, said coding sequence having a deletion of the nuclear localization signal and/or transmembrane domain;
- or (ii) a Clusterin coding sequence and a heterologous polypeptide sequence fused to said Clusterin coding sequence.
47-48. (canceled)
Dependencies are inferred from the claim text.