Compositions and methods for treating cancer
AssigneeBoard of Regents of the University of Nebraska
InventorsHamid Band, Vimla Band, Fany Iseka, Bhopal Mohapatra, Matthew Storck
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Abstract
Methods and compositions for treating cancer, particularly improved CAR-T methods, are disclosed.
Claims26
A method of treating and/or inhibiting cancer in a subject, said method comprising administering to said subject a therapeutically effective amount of T cells that express a chimeric antigen receptor,
- wherein the expression of CBL and/or CBL-B is inhibited in said T cells, and
- wherein said chimeric antigen receptor comprises an antibody or fragment thereof immunologically specific for a tumor specific surface antigen of said cancer.
An isolated T cell comprising a nucleic acid molecule encoding a chimeric antigen receptor, and wherein the expression of CBL and/or CBL-B is inhibited in said T cell.
A method of increasing the efficacy of a chimeric antigen receptor T-cell therapy comprising reducing the expression of CBL and/or CBL-B in the chimeric antigen receptor T-cells prior to administration of the T cells to a subject.
A vector comprising i) a nucleic acid sequence encoding a chimeric antigen receptor and ii) a nucleic acid sequence encoding at least one inhibitory nucleic acid molecule for CBL or CBL-B.
A kit comprising a first vector comprising a nucleic acid sequence encoding a chimeric antigen receptor and a second vector comprising a nucleic acid sequence encoding at least one inhibitory nucleic acid molecule for CBL or CBL-B.
Dependencies are inferred from the claim text.