Methods and compositions for treating and/or preventing a disease or disorder associated with abnormal level and/or activity of the ifp35 family of proteins

A method for identifying a modulator for Interferon-induced Protein 35 kD (IFP35) and/or N-Myc-interacting protein (NMI), comprising:

• a) contacting IFP35 and/or NMI with a test substance and assessing an activity of IFP35 and/or NMI that has been contacted with the test substance;
• b) assessing an activity of the IFP35 and/or NMI that has not been contacted with the test substance;
• and
• c) comparing the activities of IFP35 and/or NMI assessed in steps a) and b), and identifying the test substance as a modulator for IFP35 and/or NMI if the activities of IFP35 and/or NMI assessed in steps a) and b) are different.