Efficient chemo-enzymatic synthesis method for cyclic peptide
AssigneeNational University Corporation Hokkaido University
InventorsToshiyuki WAKIMOTO, Kenichi MATSUDA, Masakazu KOBAYASHI
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Abstract
A method for producing a cyclic peptide, comprising using a penicillin-binding protein-type thioesterase (PBP-type TE) or a tyrocidine synthase TycC thioesterase domain (TycC-TE) as a catalyst, wherein a diol as a leaving group is attached to a carboxyl group of a C-terminal residue of a substrate; and a method for producing a peptide serving as the substrate using a solid phase carrying a diol.
Claims13
A method for producing a cyclic peptide, comprising using a penicillin-binding protein-type thioesterase (PBP-type TE) or a tyrocidine synthase TycC thioesterase domain (TycC-TE) as a catalyst, wherein a diol as a leaving group is attached to a carboxyl group of a C-terminal residue of a substrate.
A kit for producing a cyclic peptide, comprising a PBP-type TE or a TycC-TE.
Dependencies are inferred from the claim text.