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US 2025/0084122 A1Published application
Volumetric absorptive microsampling devices and methods of using the same
AssigneesSangui Bio Pty Ltd, The University of Sydney
InventorsCameron John Hill, Ben Herbert, Mark Paul Molloy, Natasha Lucas
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Abstract
The object of the present invention is to provide a microsampling device that allows analysis of proteins in a biological sample, such as a whole blood sample, and provide methods of using the same.
Claims175
A method of fractionating a sample, comprising:
- a) introducing a sample into a porous material:
- b) optionally, centrifuging the porous material containing the sample:
- c) drying the sample in the porous material:
- d) extracting a first set molecules from the dried sample-containing porous material, comprising:
- 1) incubating the dried sample-containing porous material in a first extraction solution:
- 2) separating the first extraction solution from the porous material;
- and
- 3) optionally, washing the porous material:
- e) digesting proteins remaining in the porous material, comprising:
- 1) incubating the porous material in a digestion solution;
- and
- 2) separating the digestion solution from the porous material;
- f) detecting one or more molecules in the separated first extraction solution;
- and
- g) detecting one or more peptides or proteins in the digestion solution.
12 more elements
A microsampling device, comprising:
- a) a first porous material;
- b) a second porous material;
- and
- c) a tube.
1 more element
A microsampling device, comprising:
- a) a first porous material,
- b) a second porous material;
- c) a third porous material;
- and
- d) a tube.
2 more elements
A microsampling device, comprising:
- a) a first porous material;
- b) a second porous material;
- and
- c) a shaft;
- wherein the first porous material is positioned at one end of the shaft and the second porous material is located at a position along the shaft so that the first porous material and the second porous material are separated and not in physical contact with each other.
2 more elements
A microsampling device, comprising:
- a) a first porous material:
- b) a second porous material:
- c) a third porous material;
- and
- d) a shaft:
- wherein the first porous material is positioned at one end of the shaft and the second porous material and the third porous material are located at positions on the shaft so that the first porous material, the second porous material, and the third porous material are separated and not in physical contact with each other.
3 more elements
Dependencies are inferred from the claim text.