Novel dealkoxyphenylation reaction
AssigneeDaiichi Sankyo Company, Limited
InventorsTsuyoshi UEDA, Tatsuya NAKAMURA
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Abstract
To provide a method for obtaining a dealkoxyphenylation product with a high yield from a substrate such as a sugar bound to an alkoxyphenyl group through an oxygen atom. A dealkoxyphenylation product can be obtained with a high yield under mild conditions by reacting a substrate that is bound to a phenyl group substituted by C1 to C5 alkoxy at the para- or ortho-position through an oxygen atom with λ3-iodane in a fluorous alcohol and water.
Claims34
A method for producing a compound represented by the formula R—OH, comprising a step of reacting a compound represented by the formula R—OX with λ3-iodane in a fluorous alcohol and water, wherein R is a substrate, X is a phenyl group substituted by C1 to C5 alkoxy at the para- or ortho-position, and the phenyl group may optionally be further substituted.
Dependencies are inferred from the claim text.