Inhibitors of sars-cov-2

A compound defined by Formula (II) below

• or a pharmaceutically acceptable salt or prodrug thereof, wherein, as valence and stability permit,
• Ar1 and Ar2 are independently selected from aryl or heteroaryl, each optionally substituted with one or more substituents individually chosen from R5;
• Y is selected from —CO—, —SO2—, —S(═O)—, —S(O)2NR6—, —S(═O)(=NR6)—, and —CH2—;
• R is selected from aryl, heteroaryl, cycloalkyl, and cycloheteroalkyl, each optionally substituted with one or more substituents individually chosen from R5;
• R5 is chosen from hydroxy, halogen, —CN, —NO2, amino, alkylamino, dialkylamino, alkyl, haloalkyl;
• alkylthio;
• haloalkylthio;
• alkoxy, haloalkoxy, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, alkylcarbonyl, haloalkylcarbonyl, alkoxycarbonyl, haloalkoxycarbonyl, alkylaminocarbonyl, heteroalkylaminocarbonyl, dialkylaminocarbonyl, heterodialkylaminocarbonyl, sulfonamido, and sulfoximino;
• and
• R6 is chosen from hydrogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl group, each optionally substituted with one or more substituents individually chosen from R5.

A compound defined by any of Formula (III)—(XI)

• pharmaceutically acceptable salts or prodrugs thereof, wherein, as valence and stability permit,
• X is chosen from the following groups:
• Y is selected from —CO—, —SO2—, —S(═O)—, —S(O)2NR6—, —S(═O)(=NR6)—, and —CH2—;
• R is selected from aryl, heteroaryl, cycloalkyl, and cycloheteroalkyl, each optionally substituted with one or more substituents individually chosen from R5;
• R1, R2, R3, and R4 are each individually chosen from hydrogen, hydroxy, halogen, —CN, —NO2, amino, alkylamino, dialkylamino, alkyl, haloalkyl;
• alkylthio;
• haloalkylthio;
• alkoxy, haloalkoxy, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, alkylcarbonyl, haloalkylcarbonyl, alkoxycarbonyl, haloalkoxycarbonyl, alkylaminocarbonyl, heteroalkylaminocarbonyl, dialkylaminocarbonyl, and heterodialkylaminocarbonyl;
• R5 is chosen from hydroxy, halogen, —CN, —NO2, amino, alkylamino, dialkylamino, alkyl, haloalkyl;
• alkylthio;
• haloalkylthio;
• alkoxy, haloalkoxy, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, alkylcarbonyl, haloalkylcarbonyl, alkoxycarbonyl, haloalkoxycarbonyl, alkylaminocarbonyl, heteroalkylaminocarbonyl, dialkylaminocarbonyl, heterodialkylaminocarbonyl, sulfonamido, and sulfoximino;
• and
• R6 is chosen from hydrogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl group, each optionally substituted with one or more substituents individually chosen from R5.

A compound defined by Formula (XII) below

• or a pharmaceutically acceptable salt or prodrug thereof, wherein, as valence and stability permit,
• Ar1 and Ar2 are independently selected from aryl or heteroaryl, each optionally substituted with one or more substituents individually chosen from R5;
• X is chosen from the following groups:
• Y is selected from —CO—, —SO2—, —S(═O)—, —S(O)2NR6—, —S(═O)(=NR6)—, and —CH2—;
• R is selected from aryl, heteroaryl, cycloalkyl, and cycloheteroalkyl, each optionally substituted with one or more substituents individually chosen from R5;
• and
• R5 is chosen from hydroxy, halogen, —CN, —NO2, amino, alkylamino, dialkylamino, alkyl, haloalkyl;
• alkylthio;
• haloalkylthio;
• alkoxy, haloalkoxy, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, alkylcarbonyl, haloalkylcarbonyl, alkoxycarbonyl, haloalkoxycarbonyl, alkylaminocarbonyl, heteroalkylaminocarbonyl, dialkylaminocarbonyl, heterodialkylaminocarbonyl, sulfonamido, and sulfoximino;
• and
• R6 is chosen from hydrogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl group, each optionally substituted with one or more substituents individually chosen from R5.