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OwnerOleg Vechorkin, Dipendu Das +9inventors
InventorsOleg Vechorkin, Dipendu Das, Yong Li, Heeoon Han, Minh Nguyen, Robert Swyka, Hai Fen Ye, Hunter Sims, Xiaozhao Wang, Monika Scuron, Kai Liu
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The present disclosure relates to bicyclic heterocycles of Formula (I), and pharmaceutical compositions of the same, that are modulators, antagonists, or inhibitors of the G protein-coupled receptor MRGPRX2 and are useful in the treatment of MRGPRX2 dependent conditions such as inflammatory diseases.
1-169. (canceled)
A compound, which is 3-(((2,5-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)methyl)-3-(4-fluorophenyl)-N-(4-hydroxycyclohexyl)azetidine-1-carboxamide, or a pharmaceutically acceptable salt thereof.
A compound, which is 3-(((2,5-Bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)methyl)-3-(4-fluorophenyl)-N-((1r,4r)-4-hydroxycyclohexyl)azetidine-1-carboxamide, or a pharmaceutically acceptable salt thereof.
A compound, which is 3-(((2,5-Bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)methyl)-3-(4-fluorophenyl)-N-(3-hydroxycyclobutyl)azetidine-1-carboxamide, or a pharmaceutically acceptable salt thereof.
A compound, which is 3-(((2,5-Bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)methyl)-3-(4-fluorophenyl)-N-((1r,3r)-3-hydroxycyclobutyl)azetidine-1-carboxamide, or a pharmaceutically acceptable salt thereof.
A compound, which is 3-(((2,5-Bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)methyl)-3-(4-fluorophenyl)azetidine-1-sulfonamide, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.