Solid polymorphs of a flna-binding compound and its hydrochloride salts
AssigneeCassava Sciences, Inc.
InventorsMichael ZAMLOOT, Lindsay BURNS BARBIER, Shawn Anthony KUCERA
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Abstract
The preparation and properties of crystalline polymorphs and solvates of 1-benzyl-8-methyl-1,4,8-triazaspiro-[4.5]-decan-2-one free base and of the mono- and dihydrochloride salts and solvates thereof are disclosed, as is an amorphous polymorph of the dihydrochloride. A pharmaceutical composition containing one or more polymorphs and a method of using that composition are also disclosed.
Claims19
1-12. (canceled)
Crystalline 1-benzyl-8-methyl-1,4,8-triazaspiro-[4.5]-decan-2-one dihydrochloride monohydrate.
A crystalline form of 1-benzyl-8-methyl-1,4,8-triazaspiro-[4.5]-decan-2-one dihydrochloride monohydrate, wherein the crystalline form is characterized by an XRPD pattern, which when measured using Cu Kα radiation, comprises three peaks selected from the group consisting of 8.0, 13.0, 13.8, 19.1, and 20.2 2θ (±0.2° 2θ).
Dependencies are inferred from the claim text.