Compounds for targeted degradation of brd9

A compound selected from the group consisting of Formula I, Formula II, Formula III, Formula IV, Formula V, and Formula VI:

• or a pharmaceutically acceptable salt thereof;
• wherein:
• each a is independently 0, 1, or 2;
• each y is independently 0, 1, or 2;
• X3, X4, X5, and X6 are selected from the group consisting of N, CH and CR3, wherein no more than 3 of X3, X4, X5, and X6 are N;
• X7 is N or CH;
• X8 and X9 are each independently at each occurrence selected from the group consisting of N and CH;
• wherein at least one of X8 or X9 is CH;
• X12 is a 5-membered heteroaryl group with 1, 2, or 3 atoms independently selected from the group consisting of N, O, and S, wherein X12 is optionally substituted with 1, 2, or 3 groups independently selected from R3;
• X17 is aryl, heteroaryl, bicycle, or cycloalkyl, each of which is optionally substituted with 1, 2, 3, or 4 substituents independently selected from R3;
• Q1 is independently at each occurrence selected from the group consisting of NH, N(alkyl), N(haloalkyl), CH2, O, and S;
• wherein if X7 is N, then Q1 is CH2;
• R is independently at each occurrence selected from the group consisting of hydrogen, C1-C4 haloalkyl, C1-C4alkyl, fluorine, chlorine, bromine, iodine, CH2F, CHF2, CF3, CH2Cl, CHCl2, CCl3, CH2Br, CHBr2, and CBr3;
• R1 is hydrogen, C1-C4alkyl, C1-C4 haloalkyl, or cycloalkyl;
• R3 is independently at each occurrence selected from the group consisting of hydrogen, hydroxyl, alkoxy, C1-C4alkyl, C1-C4 haloalkyl, cycloalkyl, fluorine, chlorine, bromine, and iodine;
• B is selected from B1 and B2;
• B1 is selected from the group consisting of:
• B2 is selected from the group consisting of:
• X10 is C(R7)2, C(O), or O;
• X11 is heterocycle, heteroaryl, aryl, cycloalkyl, or a bicycle, each of which X11 groups is optionally substituted with 1, 2, 3, or 4 groups independently selected from R3;
• or X10 and X11 are taken together to form
• X13, X14, X15, and X16 are independently selected from the group consisting of N, CH, and CR4, wherein no more than 3 of X13, X14, X15, and X16 are N;
• each R4 is independently selected from the group consisting of hydrogen, aryl, heteroaryl, C1-C4alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, C1-C4alkyl, fluorine, chlorine, bromine, and iodine;
• wherein two R4 groups on adjacent carbon atoms may optionally combine to form a fused cycle, wherein the fused cycle is optionally substituted with 1, 2, or 3 R substituents;
• R5 is hydrogen, C1-C4alkyl, allyl, crotyl, alkenyl, alkynyl, haloalkyl, or cycloalkyl;
• each R6 is independently selected from the group consisting of hydrogen, C1-C4alkoxy, C1-C4alkyl, C1-C4 haloalkyl, fluorine, chlorine, bromine, and iodine;
• each R7 is independently hydrogen or C1-C4alkyl;
• R8 is hydrogen, C1-C4alkyl, allyl, crotyl, alkenyl, alkynyl, haloalkyl, or cycloalkyl;
• L is a bivalent Linker of formula:
• wherein:
• X1 and X2 are independently at each occurrence selected from the group consisting of bond, heterocycle, NR2, C(R2)2, O, C(O), and S;
• R2 is independently at each occurrence selected from the group consisting of hydrogen, alkyl, heterocycle, aryl, heteroaryl, —C(O)H, —C(O)OH, —C(O)alkyl, —C(O)Oalkyl, —C(O)(aryl or heteroaryl), —C(O)O(aryl or heteroaryl), alkene, and alkyne;
• R20, R21, R22, R23, and R24 are independently at each occurrence selected from the group consisting of a bond, alkyl, —C(O)—, —C(O)O—, —OC(O)—, —SO2—, —S(O)—, —C(S)—, —C(O)NR2—, —NR2C(O)—, —O—, —S—, —NR2—, —C(R40R40)—, —P(O)(OR26)O—, —P(O)(OR26)—, bicycle, alkene, alkyne, haloalkyl, alkoxy, aryl, heterocycle, heteroaryl, lactic acid, glycolic acid, and carbocycle;
• each of which is optionally substituted with 1, 2, 3, or 4 substituents independently selected from R40;
• R26 is independently at each occurrence selected from the group consisting of hydrogen, alkyl, arylalkyl, heteroarylalkyl, alkene, alkyne, aryl, heteroaryl, and heterocycle;
• and
• R40 is independently at each occurrence selected from the group consisting of hydrogen, alkyl, alkene, alkyne, fluoro, bromo, chloro, hydroxyl, alkoxy, azide, amino, cyano, —NH(alkyl), —N(alkyl)2, —NHSO2 (alkyl), —N(alkyl)SO2 alkyl, —NHSO2 (aryl, heteroaryl or heterocycle), —N(alkyl)SO2 (aryl, heteroaryl or heterocycle), —NHSO2 alkenyl, —N(alkyl)SO2 alkenyl, —NHSO2 alkynyl, —N(alkyl)SO2 alkynyl, haloalkyl, aryl, heteroaryl, heterocycle, and cycloalkyl.