Compositions and methods for inhibition of ras

A compound according to Formula II:

• or a salt (e.g., pharmaceutically acceptable salt) thereof, wherein:
• each dashed line represents a single or double bond;
• X, Y, and Z are selected from N and C, wherein one and only one of X, Y, and Z is N;
• R1 is selected from —OR7,
• and a 4-6 membered heterocycle comprising a nitrogen atom, wherein the heterocycle is unsubstituted or substituted with one or more R15;
• R2 is a 4-6 membered heterocycle containing one or more nitrogen atoms, wherein the heterocycle is unsubstituted or is substituted with one or more R8;
• when X is C, R3 is H, and when X is N, R3 is absent;
• when Y is C, R4 is selected from H, halogen, —CN, —OR12, and C1-6alkyl, wherein any C1-6alkyl is unsubstituted or substituted with one or more R11, and when Y is N, R4 is absent;
• R5 is a bicyclic heteroaryl substituted with one or more R9;
• when Z is C, R6 is selected from halogen, —OR12, —CN, and H, and when Z is N, R6 is absent;
• R7 is selected from a heterocycle and an alkylheterocycle, wherein any heterocycle comprises 4-8 members and is unsubstituted or is substituted with one or more Ra or Rb, and wherein an alkyl moiety of any alkylheterocycle is selected from C1-6 alkyl;
• each R8 is selected from halogen and C1-6alkyl, wherein any C1-6alkyl is unsubstituted or substituted with one or more R11;
• each R9 is independently selected from halogen, —N(R12)2, —CN, and C1-6alkyl, wherein any C1-6alkyl is unsubstituted or substituted with one or more R13;
• each R11 is independently selected from halogen, —OR12, and —CN;
• each R12 is independently selected from C1-6 alkyl, C2-6 alkenyl, and H, wherein any C1-6alkyl or C2-6 alkenyl is unsubstituted or substituted with one or more R13;
• each R13 is independently selected from —OR14, —CN, —N(R14)2, and halogen;
• each R14 is independently selected from C1-6 alkyl, C2-6 alkenyl, and H;
• each R15 is independently selected from halogen, —N(R14)2, C1-6alkyl, —OR14, and a 3-6 membered heterocycle, wherein any C1-6alkyl is unsubstituted or substituted with one or more R13, and any heterocycle is unsubstituted or substituted with one or more R16;
• each R16 is independently selected from —OH, —OC1-6alkyl, —CN, —NH2, —NHC1-6alkyl, and halogen;
• R17 is a 3-6 membered heterocycle including one or more heteroatoms selected from N, O, and S,
• wherein the heterocycle is unsubstituted or substituted with one or more R18;
• each R18 is independently selected from C1-6alkyl and halogen;
• and
• each Ra and Rb is independently selected from halogen, C1-6 alkyl, —OR12, and H, wherein an Ra and Rb optionally join together to form a 3-6 membered carbocycle or heterocycle, and wherein any C1-6alkyl or 3-6 membered carbocycle or heterocycle is unsubstituted or is substituted with one or more R13.