Pyrazole-substituted cyclopentanol ester derivative and use thereof

A compound of formula (I), an isomer thereof, or a pharmaceutically acceptable salt thereof,

• wherein,
• ring A is selected from the group consisting of a C3-10 alkyl ring, a 5-10 membered heteroalkyl ring, a benzene ring, a naphthyl ring, a benzene ring fused to a C5-6 alkyl ring, a benzene ring fused to a 5-6 membered heteroalkyl ring, a 5-10 membered heteroaromatic ring, a 5-6 membered heteroaromatic ring fused to a C5-6 alkyl ring, or a 5-6 membered heteroaromatic ring fused to a 5-6 membered heteroalkyl ring, and the C3-10 alkyl ring, the 5-10 membered heteroalkyl ring, the benzene ring, the naphthyl ring, the benzene ring fused to a C5-6 alkyl ring, the benzene ring fused to a 5-6 membered heteroalkyl ring, the 5-10 membered heteroaromatic ring, the 5-6 membered heteroaromatic ring fused to a C5-6 alkyl ring, or the 5-6 membered heteroaromatic ring fused to a 5-6 membered heteroalkyl ring is optionally independently substituted with 1 or more Ra;
• L1 and L2 are each independently selected from the group consisting of a single bond, —N(Rb)—, —N═, —O—, —S—, —(CH2)m—, —(CD2)m-, —(CHD)m, —C(═O)—, —S(═O)—, —S(═O)2—, —S(═O)(═N(Rb))—, —S(═O)(Rc)—, —P(═O)(Rc)—, or —P(═O)(NRbRb)—;
• R1 is selected from the group consisting of H, deuterium, C1-3 alkyl, C1-3 alkoxy, —NH2, —NH(C1-3 alkyl), —N(C1-3 alkyl)2, C3-6 cycloalkyl, 3-6 membered heterocycloalkyl, phenyl, or 5-6 membered heteroaryl;
• the C1-3 alkyl or the C1-3 alkoxy is optionally independently substituted with 1, 2 or 3 Rd, and the C3-6 cycloalkyl, the 3-6 membered heterocycloalkyl, the phenyl, or the 5-6 membered heteroaryl is optionally independently substituted with 1 or more Re;
• R2, R3, and R4 are each independently selected from the group consisting of H, deuterium, halogen, OH, CN, NH2, C1-3 alkyl, or C1-3 alkoxy, and the C1-3 alkyl or the C1-3 alkoxy is optionally independently substituted with 1 or more Rz;
• or R2 and R3, together with the carbon atom linked thereto, form C3-6 cycloalkyl or 3-6 membered heterocycloalkyl, and R4 is selected from the group consisting of H, deuterium, halogen, OH, CN, NH2, C1-3 alkyl, or C1-3 alkoxy;
• the C1-3 alkyl, the C1-3 alkoxy, the C3-6 cycloalkyl, or the 3-6 membered heterocycloalkyl is optionally independently substituted with 1 or more Rz;
• Ra is each independently selected from the group consisting of deuterium, halogen, OH, CN, NH2, ═O, C1-3 alkyl, or C1-3 alkoxy, and the C1-3 alkyl or the C1-3 alkoxy is optionally independently substituted with 1 or more Rx;
• Rb is each independently selected from the group consisting of H, C1-3 alkyl, C1-3 alkoxy, —C(═O)H, —S(═O)2C1-3 alkyl, C3-6 cycloalkyl, or 3-6 membered heterocycloalkyl;
• the C1-3 alkyl or the C1-3 alkoxy is optionally independently substituted with 1, 2 or 3 Rx, and the C3-6 cycloalkyl or the 3-6 membered heterocycloalkyl is optionally independently substituted with 1 or more Ry;
• Rc is selected from the group consisting of halogen, OH, CN, or C1-3 alkyl, and the C1-3 alkyl is optionally independently substituted with 1 or more Rx;
• Rd is each independently selected from the group consisting of deuterium, halogen, OH, CN, or NH2;
• Re is each independently selected from the group consisting of deuterium, halogen, OH, CN, NH2, ═O, C1-3 alkyl, or C1-3 alkoxy, and the C1-3 alkyl or the C1-3 alkoxy is optionally independently substituted with 1 or more Rx;
• Rx is each independently selected from the group consisting of deuterium, halogen, OH, CN, or NH2;
• Ry is each independently selected from the group consisting of deuterium, halogen, OH, CN, NH2, ═O, C1-3 alkyl, or C1-3 alkoxy, and the C1-3 alkyl or the C1-3 alkoxy is optionally independently substituted with 1 or more substituents selected from the group consisting of deuterium, halogen, OH, CN, or NH2;
• Rz is each independently selected from the group consisting of deuterium, halogen, OH, CN, or NH2;
• m is selected from the group consisting of 1, 2, or 3;
• the carbon atom with “*” is a chiral carbon atom present in a form of a single (R) or (S) enantiomer or in a form enriched with one enantiomer;
• or, L1, L2, R1, R2, R3, R4, Ra, Rb, Rc, Rd, Re, Rx, Ry, or Rz is each independently optionally substituted with one or more substituents.