4-substituted aminoisoquinoline derivatives

A compound represented by a compound of formula (IV)

• wherein
• W is alkene, alkyne, C1-8 alkyl, or heteroalkyl containing 1-8 carbon and hetero atoms;
• U, Y, and Z are each N or CR6, wherein R6 is H or NRaRb;
• R7 and R8, together with the carbon atoms to which they are attached, form a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl group, each optionally substituted with substituents independently selected from the group consisting of alkyl, cycloalkyl, alkenyl, alkynyl, halo, nitro, ORc, SRc, CN, haloalkyl, O-haloalkyl, NRaRb, (CO)Rd, (CO)ORc, (CO)NRaRb, SO2NRaRb, and —C(CH3)(=N—NHC(NH)NH2;
• Ring A is a 6-membered aryl or heteroaryl group, wherein Ring A is optionally substituted with substituents selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, halo, nitro, ORc, SRc, CN, haloalkyl, O-haloalkyl, NRmRn, (CO)Rd, (CO)ORc, SO2NRmRn, (CO)NRmRn, C(NH)NRmRn, NH(CO)Rd, NH(CO)ORc, NH(CO)NRmRn, aryl, and heteroaryl;
• Rm and Rn are each independently
• H, OH,
• alkyl, —(CH2)p-T, -aryl-(CH2)p-T, —(CH2)p-aryl-T, -heteroaryl-(CH2)p-T, —(CH2)p-heteroaryl-T, each optionally substituted with alkyl, halo, nitro, CN, haloalkyl, O-haloalkyl, ORc, SRc, NRaRb, (CO)Rd, NH(CO)Rd, NH(CO)ORc, NH(CO)NRaRb, NHC(NH)NH2, (CO)ORc, (CO)NRaRb, SO2NRaRb, arylamino, or heteroarylamino,
• or Rm and Rn, together with the nitrogen atom they are attached, form a heterocycloalkyl group, optionally substituted with alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, halo, nitro, CN, ORc, SRc, CORd, NRaRb, NH(CO)Rd, NH(CO)ORc, NH(CO)NRaRb, a guanidine group, (CO)ORc, or (CO)NRaRb;
• T is NRaRb, ORc, SRc, O—(CH2)q—NRaRb, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, a guanidine group, or an isonicotinimidamide group;
• R′ is H, alkyl, or cycloalkyl;
• Ra, Rb, Rc, and Rd are each independently H, alkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, —(CH2)q-cycloalkyl, —(CH)q-heterocycloalkyl, —(CH2)q-aryl, —(CH)q-heteroaryl, —(CO)-alkyl, —(CO)-cycloalkyl, —(CO)-heterocycloalkyl, —(SO2)-alkyl, —(SO2)-cycloalkyl, or —(SO2)-heterocycloalkyl, or Ra and Rb, together with the nitrogen atom to which they are attached, form a heterocycloalkyl group, wherein cycloalkyl, heterocycloalkyl, aryl and heteroaryl are each optionally substituted with a group consisting of alkyl, halo, nitro, CN, haloalkyl, O-haloalkyl, OH, O-alkyl, SH, S-alkyl, NH2, NH(alkyl), and N(alkyl)2;
• and
• p and q are each independently 0-8;
• or a pharmaceutically acceptable salt, N-oxide, hydrate, solvate, tautomer, or optical isomer thereof.