Novel salt of 1-sulfonyl pyrrole derivative, preparation method thereof and pharmaceutical composition comprising thereof
AssigneeIldong Pharmaceutical Co., Ltd.
InventorsHong Chul Yoon, Joon Tae Park, Jung Woo Lee, Kyung Mi An, Chang Hee Hong, Jae Eui Shin, Soo Jin Lee, Hanna Seo, Jae Hong Lee
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Abstract
The present disclosure relates to a novel salt of a 1-sulfonyl pyrrole derivative, and to a novel salt having excellent solubility in vivo, stability, bioavailability, and the like, a preparation method thereof, and a pharmaceutical composition comprising the same.
Claims17
A fumarate salt of 1-(5-(2-fluorophenyl)-4-methoxy-1-((6-methoxypyridin-3-yl) sulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine represented by the following Chemical Formula I:
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A preparation method of a fumarate salt of 1-(5-(2-fluorophenyl)-4-methoxy-1-((6-methoxypyridin-3-yl) sulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine represented by the following Chemical Formula I, comprising:
- (1) dissolving a compound represented by the following Chemical Formula (II) in a single organic solvent or a mixed solvent to react with fumaric acid;
- (2) precipitating a product from a reaction solution obtained in step (1);
- and
- (3) filtering and drying the product of step (2):
Dependencies are inferred from the claim text.