Nasal delivery devices

A method of delivering a liquid substance containing a steroid to a nasal airway of a subject, comprising:

• inserting a nosepiece into a nostril of the subject, the nosepiece having (i) a body member defining an outer sealing surface and an inner delivery channel and (ii) a nozzle, disposed in the delivery channel, through which the substance is delivered to the nasal airway of the subject;
• inserting a mouthpiece into an oral cavity of the subject, the mouthpiece configured to receive a flow of exhalation breath generated by the subject, the flow of exhalation breath configured to cause closure of an oropharyngeal velum of the subject;
• regulating the flow of exhalation breath by a flow regulator;
• manually actuating a delivery pump to move a body part of the delivery pump from a first, rest position to a second, actuated position, wherein movement of the body part from the first, rest position to the second, actuated position is configured to cause a dose of the liquid substance to be expelled out of the nozzle;
• and
• fluidly connecting the mouthpiece with the nosepiece when the body part of the delivery pump is moved from the first, rest position to the second, actuated position.

A method of treating nasal inflammation in a subject in need thereof by delivering a liquid substance containing a steroid to a nasal airway of the subject, comprising:

• inserting a nosepiece into a nostril of the subject, the nosepiece having (i) a body member defining an outer sealing surface and an inner delivery channel and (ii) a nozzle, disposed in the delivery channel, through which the substance is delivered to the nasal airway of the subject;
• inserting a mouthpiece in an oral cavity of the subject, the mouthpiece configured to receive a flow of exhalation breath generated by the subject, the flow of exhalation breath configured to cause closure of an oropharyngeal velum of the subject;
• regulating the flow of exhalation breath by a flow regulator;
• manually actuating a delivery pump to move a body part of the delivery pump from a first, rest position to a second, actuated position, wherein movement of the body part from the first, rest position to the second, actuated position is configured to cause a dose of the liquid substance to be expelled out of the nozzle;
• fluidly connecting the mouthpiece with the nosepiece when the body part of the delivery pump is moved from the first, rest position to the second, actuated position.