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US 2025/0082786 A1Published application
Fluorescent markers for neurofibrillar tangles and uses thereof
AssigneesFondazione Istituto Italiano Di Tecnologia, Disruptive Technological Advances In Life Science S.r.l. - Società Benefit (D-TAILS S.r.l. SB)
InventorsAlberto BOFFI, Francesca GHIRGA, Alessandro SOLOPERTO, Silvia DI ANGELANTONIO
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Abstract
The present invention relates to new fluorescent markers selectively binding tau protein, uses thereof, methods for imaging the neurofibrillary tangles of the tau protein in the retina of a subject, as well as a device that enables the implementation of said methods.
Claims20
A fluorescent marker selectively binding Tau protein of formula I:
- wherein X and Y are carbon atoms linked either by a double bond with E or Z configuration or by an aromatic or heteroaromatic para-substituted ring, or by an aromatic or heteroaromatic 1,4 disubstituted ring;
- R is hydrogen, halogen, NH(RA), N(RA)2, NHC(═O)RA, ORA, OC(═O)RA, SRA, SO2RA, SO3RA, OSO2RA, OSO3RA, C(RA)3, or C5-7 aromatic or aliphatic heterocycle;
- and
- in each substituent, RA is:
- hydrogen;
- halogen;
- hydroxyl;
- CF3;
- a C1-7 saturated or unsaturated chain, linear or branched containing up to three independent heteroatoms selected from the group consisting of nitrogen, oxygen, and sulphur;
- C5-7 cycloalkyl;
- phenyl;
- C5-7 heterocycle;
- or n-ethyleneglycol.
10 more elements
Dependencies are inferred from the claim text.