Chimeric influenza vaccines
AssigneeAcademia Sinica
InventorsChi-Huey WONG, Hsin-Yu LIAO, Shih-Chi WANG, Yi-An KO, Kuo-I LIN, Che MA, Ting-Jen CHENG
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Abstract
The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA).
Claims9
A method of immunizing a subject against influenza virus or preventing an influenza virus disease, comprising administering to the subject an effective amount of an immunogenic composition comprising a chimeric influenza virus hemagglutinin (HA) polypeptide and an adjuvant;
- wherein the chimeric influenza virus hemagglutinin (HA) polypeptide comprises one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA);
- wherein the chimeric influenza virus hemagglutinin (HA) polypeptide comprises an amino acid sequence of SEQ ID NO:
- 4, SEQ ID NO:
- 8, or SEQ ID NO:
- 12.
Dependencies are inferred from the claim text.