Tcr and application thereof

A TCR comprising a TCR α chain variable region and/or a TCRβ chain variable region, wherein the TCR can specifically recognize and bind to HLA-A*02:01/SLLMWITQC, the affinity KD1 of the TCR to the HLA-A*02:01/SLLMWITQC is 0.1-10 μM, or 0.39-9.3 μM, or 0.81-3.2 μM, wherein, the TCR can also specifically recognize and bind to one or more of HLA-A*02:03/SLLMWITQC, HLA-A*02:09/SLLMWITQC, HLA-A*02:12/SLLMWITQC, and HLA-A*02:16/SLLMWITQC, and the affinity KD2 is 0.1-85 μM, or 0.57-27 μM, or 1.3-10 μM;

• wherein:
• the affinity KD of the TCR to the HLA-A*02:16/SLLMWITQC is or 0.16-23 μM, or 1.3-12 μM;
• the affinity KD of the TCR to the HLA-A*02:03/SLLMWITQC is or 1.1-76 μM, or 2.3-9 μM;
• the affinity KD of the TCR to the HLA-A*02:09/SLLMWITQC is or 0.1-8.3 μM, or 0.51-5.6 μM;
• or 0.57-3 μM;
• the affinity KD of the TCR to the HLA-A*02:12/SLLMWITQC is or 0.88-85 μM, or 3-35 μM;
• or 5.1-10 μM;
• and,
• the amino acid sequences of CDR1, CDR2, and CDR3 of the TCR α chain variable region are as shown in SEQ ID NO:
• 71, SEQ ID NO:
• 72, and SEQ ID NO:
• 1 or a derived sequence of SEQ ID NO:
• 1, respectively, wherein, the derived sequence of SEQ ID NO:
• 1 is as shown in any one of SEQ ID NOs:
• 3-13 in sequence listing;
• and
• the amino acid sequences of CDR1, CDR2, and CDR3 of the TCR β chain variable region are as shown in SEQ ID NO:
• 73, SEQ ID NO:
• 74, and SEQ ID NO:
• 2 or a derived sequence of SEQ ID NO:
• 2, respectively, wherein, the derived sequence of SEQ ID NO:
• 2 is as shown in any one of SEQ ID NOs:
• 14-17 in sequence listing.