Ophthalmic composition containing recoflavone for the treatment of dry eye disease and method for preparing the same
AssigneeGl Pharmtech Corp.
InventorsEun Jung KIM, Jun Sang PARK
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Abstract
The present invention relates to an ophthalmic composition containing recoflavone for the treatment of dry eye disease. Specifically, in order to maximize the improvement of symptoms of dry eye, the present invention relates to an ophthalmic composition containing a certain concentration of the active ingredient and at least one of polyoxyethylene castor oil derivatives or poloxamers which are permeation enhancers, so that the active ingredient, recoflavone, can sufficiently penetrate the cornea in vivo to exhibit significant therapeutic effects.
Claims8
An ophthalmic composition for the treatment of dry eye disease, the composition comprising 5% (w/v) or more of recoflavone or a pharmaceutically acceptable salt thereof, a hydrate, anhydride or solvate thereof;
- a permeation enhancer in an amount of 0.1 to 5.0% (w/v);
- and
- a tonicity agent in an amount of 0.01 to 1.0% (w/v).
An ophthalmic composition for the treatment of dry eye disease, the composition comprising 5% (w/v) or more of recoflavone or a pharmaceutically acceptable salt thereof, a hydrate, anhydride or solvate thereof;
- and
- a permeation enhancer in an amount of 0.1 to 5.0% (w/v);
- 1 to 2 drops are administered at a time and at least 3 times a day.
Dependencies are inferred from the claim text.