Polymeric fluorophores, compositions comprising the same, and methods of preparing and using the same
AssigneeNorth Carolina State University
InventorsJonathan S. Lindsey, Gongfang Hu, Rui Liu
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Abstract
Described herein are polymeric fluorophores that include a dye, a polymer, and optionally a bioconjugate group. A polymeric fluorophore may have a structure represented by: A-B-C or C-A-B, wherein A is a dye; B is a polymer comprising one or more hydrophobic unit(s) and one or more hydrophilic unit(s); and optionally C, wherein C, when present, comprises a bioconjugate group. Also described herein are compositions comprising the polymeric fluorophores and methods of preparing and using the same.
Claims4
A composition comprising:
- a particle including a core and a shell, wherein the particle comprises a compound having a structure represented by:
- A-B-C, or
- C-A-B
- wherein
- A is a dye (e.g., a fluorophore);
- B is a polymer comprising one or more hydrophobic unit(s) and one or more hydrophilic unit(s);
- and
- optionally C, wherein C comprises a bioconjugate group;
- and
- water.
A method of preparing a compound comprising:
- polymerizing a hydrophobic monomer and a hydrophilic monomer to provide a co-polymer comprising a hydrophobic unit and a hydrophilic unit;
- attaching a dye to a first portion of the co-polymer, thereby providing the compound;
- and
- optionally attaching a bioconjugate group to a second portion of the co-polymer and/or
- optionally cross-linking the compound.
A biomolecule comprising a compound having a structure represented by:
- A-B-C, or
- C-A-B
- wherein
- A is a dye (e.g., a fluorophore);
- B is a polymer comprising one or more hydrophobic unit(s) and one or more hydrophilic unit(s);
- and
- optionally C, wherein C comprises a bioconjugate group;
- and
- water.
Dependencies are inferred from the claim text.